Nonclinical pharmacokinetic and pharmacodynamic assessment of bimatoprost following a single intracameral injection of sustained-release implants
Translational Vision Science & Technology, 9(4), pp.20-20
Approved Therapy
Prevention of Laser Photocoagulation Induced Choroidal Neovascularization Lesions by Intravitreal Doses of Ranibizumab in Cynomolgus Monkeys
Invest Ophthalmol Vis Sci, – electronic abstract (2009)
Safety evaluation of intravitreal administration of VEGF trap in cynomolgus monkeys for 13 weeks.
Investigative Ophthalmology & Visual Science, 47(13), pp.1751-1751.
Pharmacokinetics and ocular tissue penetration of VEGF Trap after intravitreal injections in rabbits
Investigative Ophthalmology & Visual Science, 47(13), pp.1430-1430.
26-Week Intravitreal Injection Toxicity Study with rhuFab VEGF in Cynomolgus Monkeys with an 8-Week Recovery
Association for Research in Vision and Ophthalmology Annual Meeting. Invest Ophthalmol Vis Sci., 44 – electronic abstract (2003).
Characterization of a Monkey Model of Laser-Induced Choroidal Neovascularization (CNV)
The Toxicologist, 72 (S-1): 311, (2003)
Safety Evaluation of Intravitreal Administration of rhuFab VEGF in Cynomolgus Monkeys for 3 Months
Invest Ophthalmol Vis Sci, 41 (4):S142 (2000).
Prevention of experimental choroidal neovascularization and resolution of active lesions by VEGF trap in nonhuman primates
Arch Ophthalmol. 2011 Aug;129(8):1042-52. doi: 10.1001/archophthalmol.2011.210.
ABSTRACT
OBJECTIVE: To evaluate the efficacy of systemic and intravitreous administration of VEGF Trap (aflibercept) in a nonhuman primate model of choroidal neovascularization (CNV).
Delivery of SAR 1118 to the retina via ophthalmic drops and its effectiveness in a rat streptozotocin (STZ) model of diabetic retinopathy (DR)
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5198-204. doi: 10.1167/iovs.09-5144. Epub 2010 May 5.
ABSTRACT