Endotoxin

Determination of a No Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Cynomolgus Monkeys

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J Ocul Pharmacol Ther. 2019 May;35(4):245-253. doi: 10.1089/jop.2018.0149. Epub 2019 Apr 9.

ABSTRACT

Determination of a No-Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Dutch Belted Rabbits

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Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1545-1552. doi: 10.1167/iovs.16-21356.

ABSTRACT

PURPOSE: The purpose of this study was to characterize the inflammatory response and determine a no-observable effect level (NOEL) in rabbit eyes after endotoxin intravitreal (ITV) injection.