Case Study:
The Challenge
SPONSOR GOAL
Develop a sustained-release drug formulation for an intracameral implant to treat ocular hypertension
STUDY GOAL
Correlate PK/PD/Tox data in the beagle
The Solution
Our Team
- Veterinary Ophthalmologists
- Glaucoma Specialists
- OCT Imaging Specialists
- CRO Technical Staff, IOP-Trained
Our Work
Animal Screening at Supplier
- Anterior Segment OCT for anterior chamber size.
- IOP for proper range
- Behavior for conscious IOP Quality
Ocular Surgery
- Implantation of a subcutaneous refillable infusion pump cannula to anterior chamber
Ocular PK/PD/Tox
- Intracameral injection with novel injector device
- Aqueous samples for drug analysis
- Training for quality IOP data
- OCT for appearance and safety
- Clinical ocular exams for safety