Paul Russell, PhD

Dr. Russell is a Vision Scientist in the Department of Surgical and Radiological Sciences at the University of California, Davis. His research interests include glaucoma, aqueous humor dynamics, cataract and the influence of biophysical cues on ocular cells. He has studied the trabecular meshwork extensively and has human meshwork cells to test experimental drugs in vitro. 

To learn more about Dr. Russell's research, please click here:

Recent Publications


Related Articles

Dexamethasone Stiffens Trabecular Meshwork, Trabecular Meshwork Cells, and Matrix.

Invest Ophthalmol Vis Sci. 2015 Jul 1;56(8):4447-59

Authors: Raghunathan VK, Morgan JT, Park SA, Weber D, Phinney BS, Murphy CJ, Russell P

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The intrinsic stiffness of human trabecular meshwork cells increases with senescence.

Oncotarget. 2015 Jun 20;6(17):15362-74

Authors: Morgan JT, Raghunathan VK, Chang YR, Murphy CJ, Russell P

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Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.

G3 (Bethesda). 2015 Mar 19;

Authors: Sánchez A, Roguev A, Krogan NJ, Russell P

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Wnt inhibition induces persistent increases in intrinsic stiffness of human trabecular meshwork cells.

Exp Eye Res. 2015 Mar;132:174-8

Authors: Morgan JT, Raghunathan VK, Chang YR, Murphy CJ, Russell P

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Thermally labile components of aqueous humor potently induce osteogenic potential in adipose-derived mesenchymal stem cells.

Exp Eye Res. 2015 Feb 24;

Authors: Morgan JT, Kwon HS, Wood JA, Borjesson DL, Tomarev SI, Murphy CJ, Russell P


Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif.

Proc Natl Acad Sci U S A. 2014 Dec 15;

Authors: Wang L, Limbo O, Fei J, Chen L, Kim B, Luo J, Chong J, Conaway RC, Conaway JW, Ranish JA, Kadonaga JT, Russell P, Wang D

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Biomimetic stochastic topography and electric fields synergistically enhance directional migration of corneal epithelial cells in a MMP-3 dependent manner.

Acta Biomater. 2014 Oct 10;

Authors: Gao J, Raghunathan VK, Reid B, Wei D, Diaz RC, Russell P, Murphy CJ, Zhao M

Related Articles

Automated AFM force curve analysis for determining elastic modulus of biomaterials and biological samples.

J Mech Behav Biomed Mater. 2014 Sep;37:209-18

Authors: Chang YR, Raghunathan VK, Garland SP, Morgan JT, Russell P, Murphy CJ

Related Articles

The formation of cortical actin arrays in human trabecular meshwork cells in response to cytoskeletal disruption.

Exp Cell Res. 2014 Jun 30;

Authors: Murphy KC, Morgan JT, Wood JA, Sadeli A, Murphy CJ, Russell P

Related Articles

A cell culture substrate with biologically relevant size-scale topography and compliance of the basement membrane.

Langmuir. 2014 Mar 4;30(8):2101-8

Authors: Garland SP, McKee CT, Chang YR, Raghunathan VK, Russell P, Murphy CJ

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Photopatternable and photoactive hydrogel for on-demand generation of hydrogen peroxide in cell culture.

Biomaterials. 2014 Feb;35(5):1762-70

Authors: Garland SP, Wang RY, Raghunathan VK, Lam KS, Murphy CJ, Russell P, Sun G, Pan T

Related Articles

Robust and artifact-free mounting of tissue samples for atomic force microscopy.

Biotechniques. 2014 Jan;56(1):40-2

Authors: Morgan JT, Raghunathan VK, Thomasy SM, Murphy CJ, Russell P

Related Articles

Human Trabecular Meshwork Cells Exhibit Several Characteristics of, but Are Distinct from, Adipose-Derived Mesenchymal Stem Cells.

J Ocul Pharmacol Ther. 2014 Jan 23;

Authors: Morgan JT, Wood JA, Walker NJ, Raghunathan VK, Borjesson DL, Murphy CJ, Russell P

Related Articles

Involvement of YAP, TAZ and HSP90 in Contact Guidance and Intercellular Junction Formation in Corneal Epithelial Cells.

PLoS One. 2014;9(10):e109811

Authors: Raghunathan VK, Dreier B, Morgan JT, Tuyen BC, Rose BW, Reilly CM, Russell P, Murphy CJ


Related Articles

What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease.

Exp Eye Res. 2013 Oct;115:1-12

Authors: Morgan JT, Murphy CJ, Russell P

Related Articles

Elastic modulus and collagen organization of the rabbit cornea: Epithelium to endothelium.

Acta Biomater. 2013 Sep 29;

Authors: Thomasy SM, Raghunathan VK, Winkler M, Reilly CM, Sadeli AR, Russell P, Jester JV, Murphy CJ

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Safety and immunomodulatory effects of allogeneic canine adipose-derived mesenchymal stromal cells transplanted into the region of the lacrimal gland, the gland of the third eyelid and the knee joint.

Cytotherapy. 2013 Aug 29;

Authors: Park SA, Reilly CM, Wood JA, Chung DJ, Carrade DD, Deremer SL, Seraphin RL, Clark KC, Zwingenberger AL, Borjesson DL, Hayashi K, Russell P, Murphy CJ

Related Articles

Substratum Compliance Modulates Corneal Fibroblast to Myofibroblast Transformation.

Invest Ophthalmol Vis Sci. 2013 Jul 16;

Authors: Dreier B, Thomasy SM, Mendonsa R, Raghunathan VK, Russell P, Murphy CJ

Related Articles

Early responses of vascular endothelial cells to topographic cues.

Am J Physiol Cell Physiol. 2013 May 22;

Authors: Dreier B, Gasiorowski JZ, Morgan JT, Nealey PF, Russell P, Murphy CJ

Related Articles

Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells.

Exp Eye Res. 2013 May 29;113C:66-73

Authors: Thomasy SM, Morgan JT, Wood JA, Murphy CJ, Russell P

Related Articles

Influence of extracellular matrix proteins and substratum topography on corneal epithelial cell alignment and migration.

Tissue Eng Part A. 2013 Mar 14;

Authors: Raghunathan V, McKee CT, Cheung W, Naik R, Nealey PF, Russell P, Murphy CJ


Related Articles

Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ.

Invest Ophthalmol Vis Sci. 2012 Dec 20;

Authors: Raghunathan VK, Morgan JT, Dreier B, Reilly CM, Thomasy SM, Wood JA, Ly I, Tuyen BC, Hughbanks M, Murphy CJ, Russell P

Related Articles

Nuclear and cellular alignment of primary corneal epithelial cells on topography.

J Biomed Mater Res A. 2012 Sep 11;

Authors: Raghunathan VK, McKee CT, Tocce EJ, Nealey PF, Russell P, Murphy CJ

Related Articles

The modulation of canine mesenchymal stem cells by nano-topographic cues.

Exp Cell Res. 2012 Jul 4;

Authors: Wood JA, Ly I, Borjesson DL, Nealey PF, Russell P, Murphy CJ

Related Articles

Focal adhesion kinase knockdown modulates the response of human corneal epithelial cells to topographic cues.

Acta Biomater. 2012 Jul 17;

Authors: Dreier B, Raghunathan V, Russell P, Murphy CJ

Integration of basal topographic cues and apical shear stress in vascular endothelial cells.

Biomaterials. 2012 Jun;33(16):4126-35

Authors: Morgan JT, Wood JA, Shah NM, Hughbanks ML, Russell P, Barakat AI, Murphy CJ

The Influence of a Biologically Relevant Substratum Topography on Human Aortic and Umbilical Vein Endothelial Cells.

Biophys J. 2012 Mar 7;102(5):1224-33

Authors: McKee CT, Wood JA, Ly I, Russell P, Murphy CJ

Modulation of osteogenic differentiation in hMSCs cells by submicron topographically-patterned ridges and grooves.

Biomaterials. 2012 Jan;33(1):128-36

Authors: Watari S, Hayashi K, Wood JA, Russell P, Nealey PF, Murphy CJ, Genetos DC

Related Articles

Elastic modulus determination of normal and glaucomatous human trabecular meshwork.

Invest Ophthalmol Vis Sci. 2012;53(1)

Authors: Russell P, Johnson M

Related Articles

Substratum stiffness and latrunculin B regulate matrix gene and protein expression in human trabecular meshwork cells.

Invest Ophthalmol Vis Sci. 2012;53(2):952-8

Authors: Thomasy SM, Wood JA, Kass PH, Murphy CJ, Russell P

Altered Stability of mRNAs Associated with Glaucoma Progression in Human Trabecular Meshwork Cells Following Oxidative Stress.

Invest Ophthalmol Vis Sci. 2012;53(4):1734-41

Authors: Mochizuki H, Murphy CJ, Brandt JD, Kiuchi Y, Russell P


Periocular and Intra-Articular Injection of Canine Adipose-Derived Mesenchymal Stem Cells: An In Vivo Imaging and Migration Study.

J Ocul Pharmacol Ther. 2011 Dec 16;

Authors: Wood JA, Chung DJ, Park SA, Zwingenberger AL, Reilly CM, Ly I, Walker NJ, Vernau W, Hayashi K, Wisner ER, Cannon MS, Kass PH, Cherry SR, Borjesson DL, Russell P, Murphy CJ

Topographic modulation of the orientation and shape of cell nuclei and their influence on the measured elastic modulus of epithelial cells.

Biophys J. 2011 Nov 2;101(9):2139-46

Authors: McKee CT, Raghunathan VK, Nealey PF, Russell P, Murphy CJ

The role of substratum compliance of hydrogels on vascular endothelial cell behavior.

Biomaterials. 2011 Aug;32(22):5056-64

Authors: Wood JA, Shah NM, McKee CT, Hughbanks ML, Liliensiek SJ, Russell P, Murphy CJ

Indentation versus tensile measurements of Young's modulus for soft biological tissues.

Tissue Eng Part B Rev. 2011 Jun;17(3):155-64

Authors: McKee CT, Last JA, Russell P, Murphy CJ

The effect of biophysical attributes of the ocular trabecular meshwork associated with glaucoma on the cell response to therapeutic agents.

Biomaterials. 2011 Mar;32(9):2417-23

Authors: McKee CT, Wood JA, Shah NM, Fischer ME, Reilly CM, Murphy CJ, Russell P

Substratum compliance regulates human trabecular meshwork cell behaviors and response to latrunculin B.

Invest Ophthalmol Vis Sci. 2011;52(13):9298-303

Authors: Wood JA, McKee CT, Thomasy SM, Fischer ME, Shah NM, Murphy CJ, Russell P


Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance.

J Biol Chem. 2010 Dec 24;285(52):40416-26

Authors: Mendoza-Cózatl DG, Zhai Z, Jobe TO, Akmakjian GZ, Song WY, Limbo O, Russell MR, Kozlovskyy VI, Martinoia E, Vatamaniuk OK, Russell P, Schroeder JI