Paul L. Kaufman, MD

Dr. Kaufman is a Professor in the UW Department of Ophthalmology and Visual Sciences at the University of Wisconsin School of Medicine and Public Health.  His research centers on studies of the physiology, pharmacology, morphology, cell biology, genetic manipulation, neural control, biomechanics and aging of the aqueous humor formation and drainage and accommodative mechanisms in the non-human primate, seeking to understand the pathophysiology and develop new therapies for the human diseases of glaucoma and presbyopia.

To learn more about Dr. Kaufman's research, please click here:

Recent Publications

2017

Change in Diabetic Retinopathy Through 2 Years: Secondary Analysis of a Randomized Clinical Trial Comparing Aflibercept, Bevacizumab, and Ranibizumab.

JAMA Ophthalmol. 2017 Apr 27;:

Authors: Bressler SB, Liu D, Glassman AR, Blodi BA, Castellarin AA, Jampol LM, Kaufman PL, Melia M, Singh H, Wells JA, Diabetic Retinopathy Clinical Research Network

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Latanoprostene bunod ophthalmic solution 0.024% for IOP lowering in glaucoma and ocular hypertension.

Expert Opin Pharmacother. 2017 Mar;18(4):433-444

Authors: Kaufman PL

2016

Diurnal Fluctuation of Intraocular Pressure.

Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6427

Authors: Kaufman PL

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Age-related posterior ciliary muscle restriction - A link between trabecular meshwork and optic nerve head pathophysiology.

Exp Eye Res. 2016 Jul 21;

Authors: Croft MA, Lütjen-Drecoll E, Kaufman PL

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Accommodative movements of the lens/capsule and the strand that extends between the posterior vitreous zonule insertion zone & the lens equator, in relation to the vitreous face and aging.

Ophthalmic Physiol Opt. 2016 Jan;36(1):21-32

Authors: Croft MA, Heatley G, McDonald JP, Katz A, Kaufman PL

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Effects of Latanoprost and Bimatoprost on the Expression of Molecules Relevant to Ocular Inflow and Outflow Pathways.

PLoS One. 2016;11(3):e0151644

Authors: Li X, He F, Gabelt BT, Wang Y, Cai S, Cao J, Fan N, Kaufman PL, Liu X

2015

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Anteriorly located zonular fibres as a tool for fine regulation in accommodation.

Ophthalmic Physiol Opt. 2015 Oct 21;

Authors: Flügel-Koch CM, Croft MA, Kaufman PL, Lütjen-Drecoll E

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Effect of topical latanoprost 0.005% on intraocular pressure and pupil diameter in normal and glaucomatous cats.

Vet Ophthalmol. 2015 Jul 16;

Authors: McDonald JE, Kiland JA, Kaufman PL, Bentley E, Ellinwood NM, McLellan GJ

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Rat, Mouse, and Primate Models of Chronic Glaucoma Show Sustained Elevation of Extracellular ATP and Altered Purinergic Signaling in the Posterior Eye.

Invest Ophthalmol Vis Sci. 2015 May 1;56(5):3075-3083

Authors: Lu W, Hu H, Sévigny J, Gabelt BT, Kaufman PL, Johnson EC, Morrison JC, Zode GS, Sheffield VC, Zhang X, Laties AM, Mitchell CH

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Viral Vector Effects on Exoenzyme C3 Transferase Mediated Actin Disruption and on Outflow Facility.

Invest Ophthalmol Vis Sci. 2015 Mar 17;

Authors: Slauson SR, Peters DM, Schwinn MK, Kaufman PL, Gabelt BT, Brandt CR

2014

Related Articles

Exciting directions in glaucoma.

Can J Ophthalmol. 2014 Dec;49(6):534-543

Authors: Rasmussen CA, Kaufman PL

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A randomised, controlled comparison of latanoprostene bunod and latanoprost 0.005% in the treatment of ocular hypertension and open angle glaucoma: the VOYAGER study.

Br J Ophthalmol. 2014 Dec 8;

Authors: Weinreb RN, Ong T, Scassellati Sforzolini B, Vittitow JL, Singh K, Kaufman PL, for the VOYAGER study group

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Identification of adult stem cells in Schwalbe's line region of the primate eye.

Invest Ophthalmol Vis Sci. 2014 Oct 16;

Authors: Braunger BM, Ademoglu B, Koschade SE, Fuchshofer R, Gabelt BT, Kiland JA, Hennes-Beean EA, Brunner KG, Kaufman PL, Tamm ER

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Latrunculin B Reduces Intraocular Pressure in Human Ocular Hypertension and Primary Open-Angle Glaucoma.

Transl Vis Sci Technol. 2014 Sep;3(5):1

Authors: Rasmussen CA, Kaufman PL, Ritch R, Haque R, Brazzell RK, Vittitow JL

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Neuroprotective effects of C3 exoenzyme in excitotoxic retinopathy.

Exp Eye Res. 2014 Jun 11;125C:128-134

Authors: Wang Y, Ying Wang, Yang Q, Guo L, Yin Y, Fan N, Zhou X, Cai SP, Kaufman PL, Liu X

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Morphological alterations within the peripheral fixation of the iris dilator muscle in eyes with pigmentary glaucoma.

Invest Ophthalmol Vis Sci. 2014 Jun 17;

Authors: Fluegel-Koch CM, Tektas OY, Kaufman PL, Paulsen FP, Luetjen-Drecoll E

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Prospects for Lentiviral Vector Mediated Prostaglandin F Synthase Gene Delivery in Monkey Eyes In vivo.

Curr Eye Res. 2014 Feb 21;

Authors: Lee ES, Rasmussen CA, Filla MS, Slauson SR, Kolb AW, Peters DM, Kaufman PL, Gabelt BT, Brandt CR

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Application of Canaloplasty in Glaucoma Gene Therapy: Where Are We?

J Ocul Pharmacol Ther. 2014 Feb 10;

Authors: Aktas Z, Tian B, McDonald J, Yamamato R, Larsen C, Kiland J, Kaufman PL, Rasmussen CA

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The trabecular meshwork in normal eyes and in exfoliation glaucoma.

J Glaucoma. 2014 Oct-Nov;:S15-9

Authors: Rasmussen CA, Kaufman PL

2013

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Benzalkonium Chloride and Glaucoma.

J Ocul Pharmacol Ther. 2013 Nov 8;

Authors: Rasmussen CA, Kaufman PL, Kiland JA

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EXTRALENTICULAR AND LENTICULAR ASPECTS OF ACCOMMODATION AND PRESBYOPIA IN HUMAN VS. MONKEY EYES.

Invest Ophthalmol Vis Sci. 2013 Jun 6;

Authors: Croft MA, McDonald JP, Katz A, Lin TL, Luetjen-Drecoll E, Kaufman PL

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ACCOMMODATIVE MOVEMENTS OF THE VITREOUS MEMBRANE, CHOROID, AND SCLERA IN YOUNG AND PRESBYOPIC HUMAN AND NONHUMAN PRIMATE EYES.

Invest Ophthalmol Vis Sci. 2013 Jun 6;

Authors: Croft MA, Nork TM, McDonald JP, Katz A, Luetjen-Drecoll E, Kaufman PL

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Effect of Nitric Oxide on Anterior Segment Physiology in Monkeys.

Invest Ophthalmol Vis Sci. 2013 Jun 25;

Authors: Heyne GW, Kiland JA, Kaufman PL, Gabelt BT

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A Potential Application of Canaloplasty in Glaucoma Gene Therapy.

Transl Vis Sci Technol. 2013 Jan 31;2(1)

Authors: Tian B, Kaufman PL

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Remembering bernard becker, MD, 1920-2013.

Invest Ophthalmol Vis Sci. 2013;54(13):7885-6

Authors: Kaufman PL

2012

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Iovs 2008-2012.

Invest Ophthalmol Vis Sci. 2012 Dec;53(13):8238-9

Authors: Kaufman PL

Imaging and measurement in the eye: now and ahead.

Optom Vis Sci. 2012 May;89(5):521-3

Authors: Read SA, Williams DR, Wojtkowski M, Roorda A, Nichols JJ, Mutti DO, Kaufman PL, Carney LG

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Comparisons of actin filament disruptors and Rho kinase inhibitors as potential antiglaucoma medications.

Expert Rev Ophthalmol. 2012 Apr;7(2):177-187

Authors: Tian B, Kaufman PL

Structure/Function Studies and the Effects of Memantine in Monkeys with Experimental Glaucoma.

Invest Ophthalmol Vis Sci. 2012 Mar 16;

Authors: Gabelt BT, Rasmussen CA, Tektas OY, Kim CB, Peterson JC, Nork TM, Ver Hoeve JN, Luetjen-Drecoll E, Kaufman PL

1α,25-Dihydroxyvitamin D(3) and its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), suppress intraocular pressure in non-human primates.

Arch Biochem Biophys. 2012 Feb 1;518(1):53-60

Authors: Kutuzova GD, Gabelt BT, Kiland JA, Hennes-Beann EA, Kaufman PL, Deluca HF

Remembering joanne angle, 1941-2012.

Invest Ophthalmol Vis Sci. 2012;53(4):2446-7

Authors: Kaufman PL

Advances in glaucoma treatment and management: outflow drugs.

Invest Ophthalmol Vis Sci. 2012;53(5):2495-500

Authors: Kaufman PL, Rasmussen CA

2011

Cytoskeletal drugs prevent posterior capsular opacification in human lens capsule in vitro.

Graefes Arch Clin Exp Ophthalmol. 2011 Dec 3;

Authors: Sureshkumar J, Haripriya A, Muthukkaruppan V, Kaufman PL, Tian B

Glaucoma research community and FDA look to the future, II: NEI/FDA Glaucoma Clinical Trial Design and Endpoints Symposium: measures of structural change and visual function.

Invest Ophthalmol Vis Sci. 2011 Oct;52(11):7842-51

Authors: Weinreb RN, Kaufman PL

Effect of nitric oxide compounds on monkey ciliary muscle in vitro.

Exp Eye Res. 2011 Sep;93(3):321-7

Authors: Gabelt BT, Kaufman PL, Rasmussen CA

Relationship of aqueous outflow resistance to age and total volume perfused in rhesus and cynomolgus monkeys.

Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6820-4

Authors: Kiland JA, Gabelt BT, Kaufman PL

Evaluation of rebound tonometry in non-human primates.

Exp Eye Res. 2011 Apr;92(4):268-73

Authors: Elsmo EJ, Kiland JA, Kaufman PL, McLellan GJ

Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma.

Vision Res. 2011 Jan 28;51(2):243-50

Authors: Ly T, Gupta N, Weinreb RN, Kaufman PL, Yücel YH

2010

Effect of H-7 on secondary cataract after phacoemulsification in the live rabbit eye.

J Ocul Pharmacol Ther. 2010 Dec;26(6):533-9

Authors: Tian B, Heatley GA, Filla MS, Kaufman PL

Sodium orthovanadate effect on outflow facility and intraocular pressure in live monkeys.

Exp Eye Res. 2010 Oct;91(4):486-90

Authors: Tan JC, Kiland JA, Gonzalez JM, Gabelt BT, Peters DM, Kaufman PL

Serial multifocal electroretinograms during long-term elevation and reduction of intraocular pressure in non-human primates.

Doc Ophthalmol. 2010 Jun;120(3):273-89

Authors: Nork TM, Kim CB, Heatley GA, Kaufman PL, Lucarelli MJ, Levin LA, Ver Hoeve JN

Heparin II domain of fibronectin mediates contractility through an alpha4beta1 co-signaling pathway.

Exp Cell Res. 2010 May 15;316(9):1500-12

Authors: Schwinn MK, Gonzalez JM, Gabelt BT, Sheibani N, Kaufman PL, Peters DM

COCH transgene expression in cultured human trabecular meshwork cells and its effect on outflow facility in monkey organ cultured anterior segments.

Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2060-6

Authors: Lee ES, Gabelt BT, Faralli JA, Peters DM, Brandt CR, Kaufman PL, Bhattacharya SK

Morphology and accommodative function of the vitreous zonule in human and monkey eyes.

Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1554-64

Authors: Lütjen-Drecoll E, Kaufman PL, Wasielewski R, Ting-Li L, Croft MA

Remembering Steven M. Podos, MD, 1937-2009.

Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1261-2

Authors: Candia OA, Kaufman PL

Suppression and reduction of corticosteroid-induced ocular hypertension by anecortave in sheep.

Arch Ophthalmol. 2010 Mar;128(3):365-6

Authors: Kaufman PL

Self-complementary AAV virus (scAAV) safe and long-term gene transfer in the trabecular meshwork of living rats and monkeys.

Invest Ophthalmol Vis Sci. 2010 Jan;51(1):236-48

Authors: Buie LK, Rasmussen CA, Porterfield EC, Ramgolam VS, Choi VW, Markovic-Plese S, Samulski RJ, Kaufman PL, Borrás T