Paul Fitzgerald, PhD

Dr. Fitzgerald is Professor and Chair of the Department of Cell Biology and Human Anatomy at the University of California-Davis.  His research uses genetic engineering approaches to create mice that lack beaded filament proteins.  He has discovered that the lenses of these animals develop and differentiate normally, achieving the high degree of structural order that characterizes the lens, but that they are unable to maintain that order with age. Thus, the structural order seen in the lens is inherently unstable, and the beaded filament serves to confer resistance to the age-dependent loss of structure. He now studies the structure of the beaded filament in an effort to determine how it accomplishes its mission.

To learn more about Dr. Fitzgerald's research, please click here:

Recent Publications

2016

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Probing the Local Secondary Structure of Human Vimentin with Electron Spin Echo Envelope Modulation (ESEEM) Spectroscopy.

J Phys Chem B. 2016 Dec 08;120(48):12321-12326

Authors: Liu L, Hess J, Sahu ID, FitzGerald PG, McCarrick RM, Lorigan GA

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Tropomodulin 1 Regulation of Actin Is Required for the Formation of Large Paddle Protrusions Between Mature Lens Fiber Cells.

Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4084-99

Authors: Cheng C, Nowak RB, Biswas SK, Lo WK, FitzGerald PG, Fowler VM

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Expression of the type VI intermediate filament proteins CP49 and filensin in the mouse lens epithelium.

Mol Vis. 2016;22:970-89

Authors: FitzGerald P, Sun N, Shibata B, Hess JF

2015

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Characterization of an Early-Onset, Autosomal Recessive, Progressive Retinal Degeneration in Bengal Cats.

Invest Ophthalmol Vis Sci. 2015 Aug 1;56(9):5299-308

Authors: Ofri R, Reilly CM, Maggs DJ, Fitzgerald PG, Shilo-Benjamini Y, Good KL, Grahn RA, Splawski DD, Lyons LA

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Role of Aquaporin 0 in lens biomechanics.

Biochem Biophys Res Commun. 2015 Jul 10;462(4):339-45

Authors: Sindhu Kumari S, Gupta N, Shiels A, FitzGerald PG, Menon AG, Mathias RT, Varadaraj K

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An alternative means of retaining ocular structure and improving immunoreactivity for light microscopy studies.

Mol Vis. 2015;21:428-42

Authors: Sun N, Shibata B, Hess JF, FitzGerald PG

2014

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Rapid light-induced activation of retinal microglia in mice lacking Arrestin-1.

Vision Res. 2014 Sep;102:71-9

Authors: Levine ES, Zam A, Zhang P, Pechko A, Wang X, FitzGerald P, Pugh EN, Zawadzki RJ, Burns ME

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Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.

Mech Dev. 2014 Feb;131:86-110

Authors: Manthey AL, Lachke SA, Fitzgerald PG, Mason RW, Scheiblin DA, McDonald JH, Duncan MK

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Myo/Nog cells: targets for preventing the accumulation of skeletal muscle-like cells in the human lens.

PLoS One. 2014;9(4):e95262

Authors: Gerhart J, Greenbaum M, Scheinfeld V, Fitzgerald P, Crawford M, Bravo-Nuevo A, Pitts M, George-Weinstein M

2013

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Carbon turnover in the water-soluble protein of the adult human lens.

Mol Vis. 2013;19:463-75

Authors: Stewart DN, Lango J, Nambiar KP, Falso MJ, FitzGerald PG, Rocke DM, Hammock BD, Buchholz BA

2012

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Electron paramagnetic resonance analysis of the vimentin tail domain reveals points of order in a largely disordered region and conformational adaptation upon filament assembly.

Protein Sci. 2012 Oct 25;

Authors: Hess JF, Budamagunta MS, Aziz A, Fitzgerald PG, Voss JC

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A role for γS-crystallin in the organization of actin and fiber cell maturation in the mouse lens.

FEBS J. 2012 Jun 20;

Authors: Fan J, Dong L, Mishra S, Chen Y, Fitzgerald P, Wistow G

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The structure of vimentin linker 1 and rod 1B domains characterized by site-directed spin-labeling electron paramagnetic resonance (SDSL-EPR) and x-ray crystallography.

J Biol Chem. 2012 Jun 26;

Authors: Aziz A, Hess JF, Budamagunta MS, Voss JC, Kuzin AP, Huang YJ, Xiao R, Montelione GT, Fitzgerald PG, Hunt JF

Long-term Effects of Intravitreal Injection of GMP-grade Bone Marrow Derived CD34+ Cells in NOD-SCID Mice with Acute Ischemia-Reperfusion Injury.

Invest Ophthalmol Vis Sci. 2012 Jan 12;

Authors: Park SS, Caballero S, Bauer G, Shibata B, Roth A, Fitzgerald PG, Forward KI, Zhou P, McGee J, Telander DG, Grant MB, Nolta JA

2010

Site-directed spin labeling and electron paramagnetic resonance determination of vimentin head domain structure.

J Biol Chem. 2010 May 14;285(20):15278-85

Authors: Aziz A, Hess JF, Budamagunta MS, Voss JC, Fitzgerald PG