Paul E. Miller, DVM, DAVCO

Dr. Miller is a Professor of Clinical Veterinary Ophthalmology at the University of Wisconsin-Madison, and is Board Certified by the American College of Veterinary Ophthalmologists.  He has over 25 years of experience in ocular toxicology and has performed ophthalmic evaluations in hundreds of GLP and non-GLP studies in which the eye is a target or the subject of off-target toxicity.  He has also conducted hundreds of studies in a variety of species in which the eye is being screened for off-target toxicity.

To learn more about Dr. Miller's research, please click here:

Recent Publications

2017

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Determination of a No-Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Dutch Belted Rabbits.

Invest Ophthalmol Vis Sci. 2017 Mar 01;58(3):1545-1552

Authors: Bantseev V, Miller PE, Bentley E, Schuetz C, Streit TM, Christian BJ, Farman C, Booler H, Thackaberry EA

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Evaluation of potential risk factors for development of primary angle-closure glaucoma in Bouviers des Flandres.

J Am Vet Med Assoc. 2017 Jan 01;250(1):60-67

Authors: Dubin AJ, Bentley E, Buhr KA, Miller PE

2016

Calibration of the TonoVet and Tono-Pen Vet tonometers in the porcine eye.

Vet Ophthalmol. 2016 Nov 24;:

Authors: Lewin AC, Miller PE

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Single ocular injection of a sustained-release anti-VEGF delivers 6months pharmacokinetics and efficacy in a primate laser CNV model.

J Control Release. 2016 Oct 31;:

Authors: Adamson P, Wilde T, Dobrzynski E, Sychterz C, Polsky R, Kurali E, Haworth R, Tang CM, Korczynska J, Cook F, Papanicolaou I, Tsikna L, Roberts C, Hughes-Thomas Z, Walford J, Gibson D, Warrack J, Smal J, Verrijk R, Miller PE, Nork TM, Prusakiewicz J, Streit T, Sorden S, Struble C, Christian B, Catchpole IR

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Ocular toxicity of AUY922 in pigmented and albino rats.

Toxicol Appl Pharmacol. 2016 Oct 15;309:55-62

Authors: Roman D, VerHoeve J, Schadt H, Vicart A, Walker UJ, Turner O, Richardson TA, Wolford ST, Miller PE, Zhou W, Lu H, Akimov M, Kluwe W

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Bilateral Uveitis and Hyphema in a Catalina Macaw (Ara ararauna × Ara macao ) With Multicentric Lymphoma.

J Avian Med Surg. 2016 Jun;30(2):172-8

Authors: Hausmann JC, Mans C, Gosling A, Miller JL, Chamberlin T, Dunn JR, Miller PE, Sladky KK

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Human ex-vivo action potential model for pro-arrhythmia risk assessment.

J Pharmacol Toxicol Methods. 2016 May 25;

Authors: Page G, Ratchada P, Miron Y, Steiner G, Ghetti A, Miller PE, Reynolds JA, Wang K, Greiter-Wilke A, Polonchuk L, Traebert M, Gintant GA, Abi-Gerges N

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Safety and Biodistribution Evaluation in CNGB3-deficient Mice of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia.

Hum Gene Ther Clin Dev. 2016 Mar 7;

Authors: Ye GJ, Budzynski E, Sonnentag P, Nork TM, Miller PE, McPherson L, Ver Hoeve JN, Smith L, Arndt T, Mandapati S, Robinson P, Calcedo R, Knop DR, Hauswirth WW, Chulay JD

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Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia.

Hum Gene Ther Clin Dev. 2016 Mar 8;

Authors: Ye GJ, Budzynski E, Sonnentag P, Nork TM, Miller PE, Sharma AK, Ver Hoeve JN, Smith L, Arndt T, Calcedo R, Gaskin C, Robinson P, Knop DR, Hauswirth WW, Chulay JD

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Safety and Biodistribution Evaluation in CNGB3-Deficient Mice of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia.

Hum Gene Ther Clin Dev. 2016 Mar;27(1):27-36

Authors: Ye GJ, Budzynski E, Sonnentag P, Nork TM, Miller PE, McPherson L, Ver Hoeve JN, Smith LM, Arndt T, Mandapati S, Robinson PM, Calcedo R, Knop DR, Hauswirth WW, Chulay JD

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α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors.

Gut. 2016 Feb 17;

Authors: Castro J, Harrington AM, Garcia-Caraballo S, Maddern J, Grundy L, Zhang J, Page G, Miller PE, Craik DJ, Adams DJ, Brierley SM

2015

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Ocular Adverse Events Associated with Antibody-Drug Conjugates in Human Clinical Trials.

J Ocul Pharmacol Ther. 2015 Dec;31(10):589-604

Authors: Eaton JS, Miller PE, Mannis MJ, Murphy CJ

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Species Differences in the Geometry of the Anterior Segment Differentially Affect Anterior Chamber Cell Scoring Systems in Laboratory Animals.

J Ocul Pharmacol Ther. 2015 Nov 5;

Authors: Thomasy SM, Eaton JS, Timberlake MJ, Miller PE, Matsumoto S, Murphy CJ

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Clinical Signs and Diagnosis of the Canine Primary Glaucomas.

Vet Clin North Am Small Anim Pract. 2015 Nov;45(6):1183-212

Authors: Miller PE, Bentley E

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Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-CB-hRS1, a Recombinant Adeno-Associated Virus Vector Expressing Retinoschisin.

Hum Gene Ther Clin Dev. 2015 Sep;26(3):165-76

Authors: Ye GJ, Budzynski E, Sonnentag P, Miller PE, Sharma AK, Ver Hoeve JN, Howard K, Knop DR, Neuringer M, McGill T, Stoddard J, Chulay JD

2014

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Evaluation of rebound tonometry in red-eared slider turtles (Trachemys scripta elegans).

Vet Ophthalmol. 2014 Jul;17(4):261-7

Authors: Delgado C, Mans C, McLellan GJ, Bentley E, Sladky KK, Miller PE

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Investigation of Ocular Events Associated with Taprenepag Isopropyl, a Topical EP2 Agonist in Development for Treatment of Glaucoma.

J Ocul Pharmacol Ther. 2014 Apr 10;

Authors: Yanochko GM, Affolter T, Eighmy JJ, Evans MG, Khoh-Reiter S, Lee D, Miller PE, Shiue MH, Trajkovic D, Jessen BA

2012

The effect of topical latanoprost on anterior segment anatomic relationships in normal dogs.

Vet Ophthalmol. 2012 Dec 10;

Authors: Tsai S, Almazan A, Lee SS, Li H, Conforti P, Burke J, Miller PE, Robinson MR

Iridocorneal angle measurements in mammalian species: normative data by optical coherence tomography.

Vet Ophthalmol. 2012 May 22;

Authors: Almazan A, Tsai S, Miller PE, Lee SS, Vilupuru AS, Burke JA, Robinson MR

Functional and anatomic consequences of subretinal dosing in the cynomolgus macaque.

Arch Ophthalmol. 2012 Jan;130(1):65-75

Authors: Nork TM, Murphy CJ, Kim CB, Ver Hoeve JN, Rasmussen CA, Miller PE, Wabers HD, Neider MW, Dubielzig RR, McCulloh RJ, Christian BJ

2011

Topical application of 0.005% latanoprost increases episcleral venous pressure in normal dogs.

Vet Ophthalmol. 2011 Nov 30;

Authors: Tsai S, Miller PE, Struble C, Howard S, Almazan A, Burke JA, Hughes PM, Li H, Conforti P, Lee SS, Robinson MR

Gender differences in iridocorneal angle morphology: a potential explanation for the female predisposition to primary angle closure glaucoma in dogs.

Vet Ophthalmol. 2011 Oct 17;

Authors: Tsai S, Bentley E, Miller PE, Gomes FE, Vangyi C, Wiese A, Almazan A, Li H, Conforti P, Lee SS, Robinson MR

Feline glaucoma--a comprehensive review.

Vet Ophthalmol. 2011 Sep;14 Suppl 1:15-29

Authors: McLellan GJ, Miller PE

Prevention of experimental choroidal neovascularization and resolution of active lesions by VEGF trap in nonhuman primates.

Arch Ophthalmol. 2011 Aug;129(8):1042-52

Authors: Nork TM, Dubielzig RR, Christian BJ, Miller PE, Miller JM, Cao J, Zimmer EP, Wiegand SJ

The pharmacologic assessment of a novel lymphocyte function-associated antigen-1 antagonist (SAR 1118) for the treatment of keratoconjunctivitis sicca in dogs.

Invest Ophthalmol Vis Sci. 2011 May;52(6):3174-80

Authors: Murphy CJ, Bentley E, Miller PE, McIntyre K, Leatherberry G, Dubielzig R, Giuliano E, Moore CP, Phillips TE, Smith PB, Prescott E, Miller JM, Thomas P, Scagliotti R, Esson D, Gadek T, O'Neill CA

2010

Effects of topical administration of latanoprost, timolol, or a combination of latanoprost and timolol on intraocular pressure, pupil size, and heart rate in clinically normal dogs.

Am J Vet Res. 2010 Sep;71(9):1055-61

Authors: Smith LN, Miller PE, Felchle LM

Surgical extraction of an intraocular infection of Parelaphostrongylus tenuis in a horse.

J Am Vet Med Assoc. 2010 Jul 15;237(2):196-9

Authors: Reinstein SL, Lucio-Forster A, Bowman DD, Eberhard ML, Hoberg EP, Pot SA, Miller PE

Proof of principle of ocular sparing in dogs with sinonasal tumors treated with intensity-modulated radiation therapy.

Vet Radiol Ultrasound. 2010 Sep-Oct;51(5):561-70

Authors: Lawrence JA, Forrest LJ, Turek MM, Miller PE, Mackie TR, Jaradat HA, Vail DM, Dubielzig RR, Chappell R, Mehta MP