Lauren Trepanier, DVM, PhD

Dr. Trepanier is a Professor of Medicine at the University of Wisconsin School of Veterinary Medicine. She is Board Certified by the American College of Veterinary Internal Medicine and the American College of Veterinary Clinical Pharmacology. Her research interests include idiosyncratic drug toxicity, pharmacogenetics, and comparative drug biotransformation among species.

To learn more about Dr. Trepanier's research, please click here:

Recent Publications

2017

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Hepatic expression profiles in retroviral infection: relevance to drug hypersensitivity risk.

Pharmacol Res Perspect. 2017 Jun;5(3):e00312

Authors: Wong YY, Johnson B, Friedrich TC, Trepanier LA

2016

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Immunogenicity of trimethoprim/sulfamethoxazole in a macaque model of HIV infection.

Toxicology. 2016 Aug 23;368-369:10-18

Authors: Wong YY, Rakasz EG, Gasper DJ, Friedrich TC, Trepanier LA

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Genome-Wide Association Study in Immunocompetent Patients with Delayed Hypersensitivity to Sulfonamide Antimicrobials.

PLoS One. 2016;11(6):e0156000

Authors: Reinhart JM, Motsinger-Reif A, Dickey A, Yale S, Trepanier LA

2015

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Transient cold agglutinins associated with Mycoplasma cynos pneumonia in a dog.

Vet Clin Pathol. 2015 Sep 10;

Authors: Pinkos AC, Friedrichs KR, Monaghan KN, Sample SH, Trepanier LA

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Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy.

J Allergy Clin Immunol. 2015 Aug;136(2):262-71.e2

Authors: Wheatley LM, Plaut M, Schwaninger JM, Banerji A, Castells M, Finkelman FD, Gleich GJ, Guttman-Yassky E, Mallal SA, Naisbitt DJ, Ostrov DA, Phillips EJ, Pichler WJ, Platts-Mills TA, Roujeau JC, Schwartz LB, Trepanier LA

2014

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Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women.

Cancer Causes Control. 2014 Sep 16;

Authors: Blanke KL, Sacco JC, Millikan RC, Olshan AF, Luo J, Trepanier LA

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Therapeutic serum phenobarbital concentrations obtained using chronic transdermal administration of phenobarbital in healthy cats.

J Feline Med Surg. 2014 Aug 6;

Authors: Delamaide Gasper JA, Barnes Heller HL, Robertson M, Trepanier LA

2013

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Cutaneous pythiosis in two dogs from Wisconsin, USA.

Vet Dermatol. 2013 Dec 28;

Authors: Oldenhoff W, Grooters A, Pinkerton ME, Knorr J, Trepanier L

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Use of Linezolid to Treat MRSP Bacteremia and Discospondylitis in a Dog.

J Am Anim Hosp Assoc. 2013 Nov 11;

Authors: Foster JD, Trepanier LA, Ginn JA

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Applying pharmacokinetics to veterinary clinical practice.

Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):1013-26

Authors: Trepanier LA

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Idiosyncratic drug toxicity affecting the liver, skin, and bone marrow in dogs and cats.

Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):1055-66

Authors: Trepanier LA

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Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics.

Drug Metab Rev. 2013 Feb 25;

Authors: Martinez MN, Antonovic L, Court M, Dacasto M, Fink-Gremmels J, Kukanich B, Locuson C, Mealey K, Myers MJ, Trepanier L

2012

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Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity.

Pharmacogenet Genomics. 2012 Jul 30;

Authors: Sacco JC, Abouraya M, Motsinger-Reif A, Yale SH, McCarty CA, Trepanier LA

2011

Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis.

J Vet Emerg Crit Care (San Antonio). 2011 Oct;21(5):547-51

Authors: Foy DS, Trepanier LA, Shelton GD

Individual variability in the detoxification of carcinogenic arylhydroxylamines in human breast.

Toxicol Sci. 2011 Jun;121(2):245-56

Authors: Rhoads K, Sacco JC, Drescher N, Wong A, Trepanier LA

Evaluation of sulfonamide detoxification pathways in haematologic malignancy patients prior to intermittent trimethoprim-sulfamethoxazole prophylaxis.

Br J Clin Pharmacol. 2011 Apr;71(4):566-74

Authors: Abouraya M, Sacco JC, Kahl BS, Trepanier LA

Dapsone-Associated Methemoglobinemia in a Patient With Slow NAT2*5B Haplotype and Impaired Cytochrome b 5 Reductase Activity.

J Clin Pharmacol. 2011 Mar 21;

Authors: Abouraya M, Sacco JC, Hayes K, Thomas S, Kitchens CS, Trepanier LA

2010

Antifungal treatment of small animal veterinary patients.

Vet Clin North Am Small Anim Pract. 2010 Nov;40(6):1171-88

Authors: Foy DS, Trepanier LA

Combined ascorbate and glutathione deficiency leads to decreased cytochrome b5 expression and impaired reduction of sulfamethoxazole hydroxylamine.

Arch Toxicol. 2010 Aug;84(8):597-607

Authors: Bhusari S, Abouraya M, Padilla ML, Pinkerton ME, Drescher NJ, Sacco JC, Trepanier LA

Acute vomiting in cats: rational treatment selection.

J Feline Med Surg. 2010 Mar;12(3):225-30

Authors: Trepanier L

Cytochrome b5 and NADH cytochrome b5 reductase: genotype-phenotype correlations for hydroxylamine reduction.

Pharmacogenet Genomics. 2010 Jan;20(1):26-37

Authors: Sacco JC, Trepanier LA

Clinical presentation of 26 anaplasma phagocytophilum-seropositive dogs residing in an endemic area.

J Am Anim Hosp Assoc. 2010 Nov-Dec;46(6):405-12

Authors: Mazepa AW, Kidd LB, Young KM, Trepanier LA