Judith West-Mays, PhD

Dr. Judith West-Mays is a Professor in the Department of Pathology and Molecular Medicine and Assistant Dean of the Medical Sciences Graduate Program at McMaster University, Ontario, Canada. She is an experienced vision scientist who obtained her Ph.D.  from the School of Optometry at the University of Waterloo. She completed 3 years of Postdoctoral studies at Harvard Medical School and was recruited to McMaster in 2002 from the Tufts Center for Vision Research in Boston where she held a prestigious Career Award from Research to Prevent Blindness. Dr. West-Mays has extensive experience in investigating the molecular and genetic mechanisms of both eye development and disease. Specifically, she utilizes genetic mouse models and cell culture studies for determining the underlying causes of primary and secondary cataracts, glaucoma, and more recently, retinal degeneration. 

To learn more about Dr. West-Mays research, please click here:

Recent Publications

2017

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Dual function of TGFβ in lens epithelial cell fate: implications for secondary cataract.

Mol Biol Cell. 2017 Feb 16;:

Authors: Boswell BA, Korol A, West-Mays JA, Musil LS

2016

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Aberrant Collagen Composition of the Trabecular Meshwork Results in Reduced Aqueous Humor Drainage and Elevated IOP in MMP-9 Null Mice.

Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):5984-5995

Authors: De Groef L, Andries L, Siwakoti A, Geeraerts E, Bollaerts I, Noterdaeme L, Etienne I, Papageorgiou AP, Stalmans I, Billen J, West-Mays JA, Moons L

β-Catenin/CBP-Dependent Signaling Regulates TGF-β-Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells.

Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5736-5747

Authors: Taiyab A, Korol A, Deschamps PA, West-Mays JA

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RhoA/ROCK signaling regulates TGFβ-induced epithelial-mesenchymal transition of lens epithelial cells through MRTF-A.

Mol Med. 2016 Sep 29;22:

Authors: Korol A, Taiyab A, West-Mays JA

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Conditional deletion of AP-2β in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma.

Dis Model Mech. 2016 Aug 1;9(8):849-61

Authors: Martino VB, Sabljic T, Deschamps P, Green RM, Akula M, Peacock E, B

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Matrix metalloproteinase 9 is associated with peritoneal membrane solute transport and induces angiogenesis through β-catenin signaling.

Nephrol Dial Transplant. 2016 May 4;

Authors: Padwal M, Siddique I, Wu L, Tang K, Bovin F, Liu L, Robertson J, Bridgewater D, West-Mays J, Gangji A, Brimble KS, Margetts PJ

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AP-2β Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development.

Invest Ophthalmol Vis Sci. 2016 Mar 1;57(3):1072-81

Authors: Chen L, Martino V, Dombkowski A, Williams T, West-Mays J, Gage PJ

2014

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AP-2α is required after lens vesicle formation to maintain lens integrity.

Dev Dyn. 2014 Oct;243(10):1298-309

Authors: Kerr CL, Zaveri MA, Robinson ML, Williams T, West-Mays JA

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Matrix metalloproteinase-9-null mice are resistant to TGF-β-induced anterior subcapsular cataract formation.

Am J Pathol. 2014 Jul;184(7):2001-12

Authors: Korol A, Pino G, Dwivedi D, Robertson JV, Deschamps PA, West-Mays JA

2013

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Altered expression of transforming growth factor beta 1 and matrix metalloproteinase-9 results in elevated intraocular pressure in mice.

Mol Vis. 2013;19:684-95

Authors: Robertson JV, Siwakoti A, West-Mays JA

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Nuclear translocation of myocardin-related transcription factor-A during transforming growth factor beta-induced epithelial to mesenchymal transition of lens epithelial cells.

Mol Vis. 2013;19:1017-28

Authors: Gupta M, Korol A, West-Mays JA

2012

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Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation.

Invest Ophthalmol Vis Sci. 2012 Jun;53(7):3316-30

Authors: Kerr CL, Huang J, Williams T, West-Mays JA

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Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina.

Dev Dyn. 2012 Apr;241(4):814-29

Authors: Bassett EA, Korol A, Deschamps PA, Buettner R, Wallace VA, Williams T, West-Mays JA

2010

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Corneal epithelial cell adhesion and growth on EGF-modified aminated PDMS.

J Biomed Mater Res A. 2010 Jun 1;93(3):1043-9

Authors: Klenkler BJ, Dwivedi D, West-Mays JA, Sheardown H

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AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis.

Hum Mol Genet. 2010 May 1;19(9):1791-804

Authors: Bassett EA, Williams T, Zacharias AL, Gage PJ, Fuhrmann S, West-Mays JA

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Platelet derived growth factor B and epithelial mesenchymal transition of peritoneal mesothelial cells.

Matrix Biol. 2010 Mar;29(2):97-106

Authors: Patel P, West-Mays J, Kolb M, Rodrigues JC, Hoff CM, Margetts PJ

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Development and use of the lens epithelial explant system to study lens differentiation and cataractogenesis.

Prog Retin Eye Res. 2010 Mar;29(2):135-43

Authors: West-Mays JA, Pino G, Lovicu FJ

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Effect of delivery of MMP inhibitors from PDMS as a model IOL material on PCO markers.

Biomaterials. 2010 Mar;31(8):2399-407

Authors: Morarescu D, West-Mays JA, Sheardown HD

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Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats.

Invest Ophthalmol Vis Sci. 2010 Jan;51(1):308-18

Authors: Robertson JV, Golesic E, Gauldie J, West-Mays JA