Curtis R. Brandt, PhD

Dr. Brandt is a Professor in the Departments of Ophthalmology and Visual Sciences, Medical Microbiology and Immunology, and the Clinical Cancer Center at the University of Wisconsin-Madison. His primary research interest is virology, specifically pathogenesis of herpes simplex virus; virulence genes in herpetic eye disease and herpes encephalitis; antivirals; interactions between cytokines and herpes viruses, gene delivery, and gene therapy.

To learn more about Dr. Brandt's research, please click here:

Recent Publications


A Mouse Model of Multi-Drug Resistant Staphylococcus aureus-induced Ocular Disease.

J Ocul Biol. 2016 Nov;4(2):

Authors: Broekema NM, Larsen IV, Naruzawa ES, Filutowicz M, Kolb AW, Teixeira LB, Brandt CR

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Mapping Murine Corneal Neovascularization and Weight Loss Virulence Determinants in the HSV-1 Genome and the Detection of an Epistatic Interaction between the UL and IRS/US Regions.

J Virol. 2016 Jul 6;

Authors: Lee K, Kolb AW, Larsen I, Craven M, Brandt CR

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Primate neural retina upregulates IL-6 and IL-10 in response to a herpes simplex vector suggesting the presence of a pro-/anti-inflammatory axis.

Exp Eye Res. 2016 May 8;148:12-23

Authors: Sauter MM, Brandt CR

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Quantitative Trait Locus Based Virulence Determinant Mapping of the HSV-1 Genome in Murine Ocular Infection: Genes Involved in Viral Regulatory and Innate Immune Networks Contribute to Virulence.

PLoS Pathog. 2016 Mar;12(3):e1005499

Authors: Kolb AW, Lee K, Larsen I, Craven M, Brandt CR

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Effect of a Soluble Epoxide Hydrolase Inhibitor, UC1728, on LPS-Induced Uveitis in the Rabbit.

J Ocul Biol. 2016 Jan;4(1):

Authors: McLellan GJ, Aktas Z, Hennes-Beean E, Kolb AW, Larsen IV, Schmitz EJ, Clausius HR, Yang J, Hwang SH, Morisseau C, Inceoglu B, Hammock BD, Brandt CR


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Genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains.

J Virol. 2015 Jun;89(12):6427-34

Authors: Kolb AW, Larsen IV, Cuellar JA, Brandt CR

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Recombination Analysis of Herpes Simplex Virus Type 1 Reveals a Bias towards GC Content and the Inverted Repeat Regions.

J Virol. 2015 Apr 29;

Authors: Lee K, Kolb AW, Sverchkov Y, Cuellar JA, Craven M, Brandt CR

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Viral Vector Effects on Exoenzyme C3 Transferase Mediated Actin Disruption and on Outflow Facility.

Invest Ophthalmol Vis Sci. 2015 Mar 17;

Authors: Slauson SR, Peters DM, Schwinn MK, Kaufman PL, Gabelt BT, Brandt CR


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Peptide Therapeutics for Treating Ocular Surface Infections.

J Ocul Pharmacol Ther. 2014 Sep 24;

Authors: Brandt CR

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Oligonucleotides designed to inhibit TLR9 block Herpes simplex virus type 1 infection at multiple steps.

Antiviral Res. 2014 Jul 1;109C:83-96

Authors: Sauter MM, Gauger JJ, Brandt CR

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Prospects for Lentiviral Vector Mediated Prostaglandin F Synthase Gene Delivery in Monkey Eyes In vivo.

Curr Eye Res. 2014 Feb 21;

Authors: Lee ES, Rasmussen CA, Filla MS, Slauson SR, Kolb AW, Peters DM, Kaufman PL, Gabelt BT, Brandt CR


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Using HSV-1 Genome Phylogenetics to Track Past Human Migrations.

PLoS One. 2013;8(10):e76267

Authors: Kolb AW, Ané C, Brandt CR

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A Cationic Peptide, TAT-Cd0, Inhibits Herpes Simplex Virus Type 1 Ocular Infection In Vivo.

Invest Ophthalmol Vis Sci. 2013;54(2):1070-9

Authors: Jose GG, Larsen IV, Gauger J, Carballo E, Stern R, Brummel R, Brandt CR


Ocular Distribution, Spectrum of Activity, and In Vivo Viral Neutralization of a Fully Humanized Anti-Herpes Simplex Virus IgG Fab Fragment following Topical Application.

Antimicrob Agents Chemother. 2012 Mar;56(3):1390-402

Authors: Berdugo M, Larsen IV, Abadie C, Deloche C, Kowalczuk L, Touchard E, Dubielzig R, Brandt CR, Behar-Cohen F, Combette JM

Antiviral activity of the EB peptide against zoonotic poxviruses.

Virol J. 2012;9:6

Authors: Altmann SE, Brandt CR, Jahrling PB, Blaney JE


Virus aggregating peptide enhances the cell-mediated response to influenza virus vaccine.

Vaccine. 2011 Oct 13;29(44):7696-703

Authors: Jones JC, Settles EW, Brandt CR, Schultz-Cherry S

Sequence variation in the herpes simplex virus U(S)1 ocular virulence determinant.

Invest Ophthalmol Vis Sci. 2011 Jun;52(7):4630-8

Authors: Kolb AW, Schmidt TR, Dyer DW, Brandt CR

Identification of the minimal active sequence of an anti-influenza virus peptide.

Antimicrob Agents Chemother. 2011 Apr;55(4):1810-3

Authors: Jones JC, Settles EW, Brandt CR, Schultz-Cherry S

Evaluation of therapeutic interventions for vaccinia virus keratitis.

J Infect Dis. 2011 Mar 1;203(5):683-90

Authors: Altmann S, Brandt CR, Murphy CJ, Patnaikuni R, Takla T, Toomey M, Nesbit B, McIntyre K, Covert J, Dubielzig R, Leatherberry G, Adkins E, Kodihalli S

Multiplex sequencing of seven ocular herpes simplex virus type-1 genomes: phylogeny, sequence variability, and SNP distribution.

Invest Ophthalmol Vis Sci. 2011;52(12):9061-73

Authors: Kolb AW, Adams M, Cabot EL, Craven M, Brandt CR


A cationic TAT peptide inhibits Herpes simplex virus type 1 infection of human corneal epithelial cells.

J Ocul Pharmacol Ther. 2010 Dec;26(6):541-7

Authors: Larsen IV, Brandt CR

The virucidal EB peptide protects host cells from herpes simplex virus type 1 infection in the presence of serum albumin and aggregates proteins in a detergent-like manner.

Antimicrob Agents Chemother. 2010 Oct;54(10):4275-89

Authors: Bultmann H, Girdaukas G, Kwon GS, Brandt CR

Kinetics of immune cell infiltration in vaccinia virus keratitis.

Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4541-8

Authors: Altmann S, Toomey M, Nesbit B, McIntyre K, Covert J, Dubielzig RR, Leatherberry G, Adkins E, Murphy CJ, Brandt CR

A quantitative rabbit model of vaccinia keratitis.

Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4531-40

Authors: Altmann S, Emanuel A, Toomey M, McIntyre K, Covert J, Dubielzig RR, Leatherberry G, Murphy CJ, Kodihalli S, Brandt CR

COCH transgene expression in cultured human trabecular meshwork cells and its effect on outflow facility in monkey organ cultured anterior segments.

Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2060-6

Authors: Lee ES, Gabelt BT, Faralli JA, Peters DM, Brandt CR, Kaufman PL, Bhattacharya SK