Christopher J. Murphy, DVM, PhD, DACVO

Dr.Murphy is a founder, serves as CEO, and provides consulting in veterinary ophthalmology.

Dr. Murphy is a Board Certified Veterinary Ophthalmologist, and Professor of Comparative Ophthalmology in the Schools of Veterinary Medicine & Medicine, University of California-Davis. Dr. Murphy has advanced training and expertise in corneal diseases and surgery, comparative physiological optics, comparative ocular anatomy, as well as ocular diseases of laboratory and exotic animal species.

His laboratory has several active areas of research:

  • Modulation of cell behaviors by biophysical attributes of the extracellular matrix:  With many collaborators,  Dr. Murphy is determining how biophysical attributes (nanoscale topography and compliance) of the extracellular matrix modulate fundamental cell behaviors such as orientation, adhesion, migration differentiation and proliferation.  These studies have relevance to improved design of biomaterials as well as increasing our understanding of the microenvironment of cells in health and disease.
  • Modulation of wound healing using engineering principals: A large interdisciplinary team is engaged in developing novel approaches to accelerate wound healing of the cornea and skin through funtionalzing wound beds rather than treating with standard soluble factors.  The central concept is that improved wound healing outcomes can be achieved through "changing the wound" surface chemistry and biophysical attributes rather than treating the wound with soluble factors.
  • Comparative ocular functional morphology: Dr. Murphy studies how various animals have evolved unique optical adaptations for optimizing their visual performance under challenging environmental conditions.
  • Development of improved solutions for organ storage prior to transplantation: In collaboration with Professor Jon McAnulty, transplant surgeon at the School of Veterinary Medicine, Dr. Murphy has found that the addition of a unique combination of trophic factors can markedly extend the time that an organ can be stored and improve its performance once it is transplanted.

Standard services to industry provided by Dr. Murphy's laboratories include performance of in-vitro cytotoxicity assays using primary cultures from human ocular cell lines (cornea and trabecular meshwork) and conducting proof of principal studies using animal models.

To learn more about Dr. Murphy's research, please click here:

 

Recent Publications

2017

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Genetic analysis of optic nerve head coloboma in the Nova Scotia Duck Tolling Retriever identifies discordance with the NHEJ1 intronic deletion (collie eye anomaly mutation).

Vet Ophthalmol. 2017 Jul 12;:

Authors: Brown EA, Thomasy SM, Murphy CJ, Bannasch DL

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Tissue and cellular biomechanics during corneal wound injury and repair.

Acta Biomater. 2017 May 27;:

Authors: Raghunathan VK, Thomasy SM, Strøm P, Yañez-Soto B, Garland SP, Sermeno J, Reilly CM, Murphy CJ

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Cascading Effects of Nanoparticle Coatings: Surface Functionalization Dictates the Assemblage of Complexed Proteins and Subsequent Interaction with Model Cell Membranes.

ACS Nano. 2017 May 22;:

Authors: Melby ES, Lohse SE, Park JE, Vartanian AM, Putans RA, Abbott HB, Hamers RJ, Murphy CJ, Pedersen JA

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Growth-Based Bacterial Viability Assay for Interference-Free and High-Throughput Toxicity Screening of Nanomaterials.

Anal Chem. 2017 Feb 07;89(3):2057-2064

Authors: Qiu TA, Nguyen TH, Hudson-Smith NV, Clement PL, Forester DC, Frew H, Hang MN, Murphy CJ, Hamers RJ, Feng ZV, Haynes CL

Quantification of Free Polyelectrolytes Present in Colloidal Suspension, Revealing a Source of Toxic Responses for Polyelectrolyte-Wrapped Gold Nanoparticles.

Anal Chem. 2017 Jan 10;:

Authors: Qiu TA, Torelli MD, Vartanian AM, Rackstraw NB, Buchman JT, Jacob LM, Murphy CJ, Hamers RJ, Haynes CL

2016

Assessment of tear film osmolarity using the TearLab(™) osmometer in normal dogs and dogs with keratoconjunctivitis sicca.

Vet Ophthalmol. 2016 Oct 20;:

Authors: Sebbag L, Park SA, Kass PH, Maggs DJ, Attar M, Murphy CJ

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Species variation and spatial differences in mucin expression from corneal epithelial cells.

Exp Eye Res. 2016 Sep 8;152:43-48

Authors: Leonard BC, Yañez-Soto B, Raghunathan VK, Abbott NL, Murphy CJ

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Biomechanical relationships between the corneal endothelium and Descemet's membrane.

Exp Eye Res. 2016 Sep 14;152:57-70

Authors: Ali M, Raghunathan V, Li JY, Murphy CJ, Thomasy SM

Intravitreal Administration of Human Bone Marrow CD34+ Stem Cells in a Murine Model of Retinal Degeneration.

Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4125-35

Authors: Moisseiev E, Smit-McBride Z, Oltjen S, Zhang P, Zawadzki RJ, Motta M, Murphy CJ, Cary W, Annett G, Nolta JA, Park SS

Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease.

Cornea. 2016 Aug 17;

Authors: Horikawa T, Thomasy SM, Stanley AA, Calderon AS, Li J, Linton LL, Murphy CJ

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In Vivo Imaging of Corneal Endothelial Dystrophy in Boston Terriers: A Spontaneous, Canine Model for Fuchs' Endothelial Corneal Dystrophy.

Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT495-503

Authors: Thomasy SM, Cortes DE, Hoehn AL, Calderon AC, Li JY, Murphy CJ

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Presumptive keratoglobus in a great horned owl (Bubo virginianus).

Vet Ophthalmol. 2016 Jul 31;

Authors: Lau RK, Moresco A, Woods SJ, Reilly CM, Hawkins MG, Murphy CJ, Hollingsworth SR, Hacker D, Freeman KS

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Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials.

Environ Sci Technol. 2016 Jun 21;50(12):6124-45

Authors: Holden PA, Gardea-Torresdey JL, Klaessig F, Turco RF, Mortimer M, Hund-Rinke K, Cohen Hubal EA, Avery D, Barceló D, Behra R, Cohen Y, Deydier-Stephan L, Ferguson PL, Fernandes TF, Herr Harthorn B, Henderson WM, Hoke RA, Hristozov D, Johnston JM, Kane AB, Kapustka L, Keller AA, Lenihan HS, Lovell W, Murphy CJ, Nisbet RM, Petersen EJ, Sali

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Heat-shock protein expression in canine corneal wound healing.

Vet Ophthalmol. 2016 May;19(3):262-6

Authors: Peterson CW, Carter RT, Bentley E, Murphy CJ, Chandler HL

2015

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Effect of Stratification on Surface Properties of Corneal Epithelial Cells.

Invest Ophthalmol Vis Sci. 2015 Dec 1;56(13):8340-8

Authors: Yáñez-Soto B, Leonard BC, Raghunathan VK, Abbott NL, Murphy CJ

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Ocular Adverse Events Associated with Antibody-Drug Conjugates in Human Clinical Trials.

J Ocul Pharmacol Ther. 2015 Dec;31(10):589-604

Authors: Eaton JS, Miller PE, Mannis MJ, Murphy CJ

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Species Differences in the Geometry of the Anterior Segment Differentially Affect Anterior Chamber Cell Scoring Systems in Laboratory Animals.

J Ocul Pharmacol Ther. 2015 Nov 5;

Authors: Thomasy SM, Eaton JS, Timberlake MJ, Miller PE, Matsumoto S, Murphy CJ

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Gallium-Loaded Dissolvable Microfilm Constructs that Provide Sustained Release of Ga(3+) for Management of Biofilms.

Adv Healthc Mater. 2015 Nov 24;

Authors: Herron M, Schurr MJ, Murphy CJ, McAnulty JF, Czuprynski CJ, Abbott NL

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Companion animals: Translational scientist's new best friends.

Sci Transl Med. 2015 Oct 7;7(308):308ps21

Authors: Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB, Chen X, Griffiths LG, Verstraete FJ, Murphy CJ, Borjesson DL

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Inhibition of Pseudomonas aeruginosa biofilm formation on wound dressings.

Wound Repair Regen. 2015 Sep 5;

Authors: Brandenburg KS, Calderon DF, Kierski PR, Brown AL, Shah NM, Abbott NL, Schurr MJ, Murphy CJ, McAnulty JF, Czuprynski CJ

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Dexamethasone Stiffens Trabecular Meshwork, Trabecular Meshwork Cells, and Matrix.

Invest Ophthalmol Vis Sci. 2015 Jul 1;56(8):4447-59

Authors: Raghunathan VK, Morgan JT, Park SA, Weber D, Phinney BS, Murphy CJ, Russell P

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Biological Responses to Engineered Nanomaterials: Needs for the Next Decade.

ACS Cent Sci. 2015 Jun 24;1(3):117-23

Authors: Murphy CJ, Vartanian AM, Geiger FM, Hamers RJ, Pedersen J, Cui Q, Haynes CL, Carlson EE, Hernandez R, Klaper RD, Orr G, Rosenzweig Z

Gross anatomy and morphometric evaluation of the canine lacrimal and third eyelid glands.

Vet Ophthalmol. 2015 Jun 15;

Authors: Park SA, Taylor KT, Zwingenberger AL, Reilly CM, Toupadakis CA, Marfurt CF, Good KL, Murphy CJ

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In vivo ocular imaging of the cornea of the normal female laboratory beagle using confocal microscopy.

Vet Ophthalmol. 2015 Mar 6;

Authors: Strom AR, Cortés DE, Thomasy SM, Kass PH, Mannis MJ, Murphy CJ

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Effects of charge and surface ligand properties of nanoparticles on oxidative stress and gene expression within the gut of Daphnia magna.

Aquat Toxicol. 2015 Feb 28;162C:1-9

Authors: Dominguez GA, Lohse SE, Torelli MD, Murphy CJ, Hamers RJ, Orr G, Klaper RD

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In vivo evaluation of the cornea and conjunctiva of the normal laboratory beagle using time- and Fourier-domain optical coherence tomography and ultrasound pachymetry.

Vet Ophthalmol. 2015 Feb 10;

Authors: Strom AR, Cortés DE, Rasmussen CA, Thomasy SM, McIntyre K, Lee SF, Kass PH, Mannis MJ, Murphy CJ

Importance of defining experimental conditions in a mouse excisional wound model.

Wound Repair Regen. 2015 Feb 19;

Authors: Park SA, Covert J, Teixeira L, Motta MJ, DeRemer SL, Abbott NL, Dubielzig R, Schurr M, Isseroff RR, McAnulty JF, Murphy CJ

Thermally labile components of aqueous humor potently induce osteogenic potential in adipose-derived mesenchymal stem cells.

Exp Eye Res. 2015 Feb 23;

Authors: Morgan JT, Kwon HS, Wood JA, Borjesson DL, Tomarev SI, Murphy CJ, Russell P

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Wnt inhibition induces persistent increases in intrinsic stiffness of human trabecular meshwork cells.

Exp Eye Res. 2015 Jan 30;132C:174-178

Authors: Morgan JT, Raghunathan VK, Chang YR, Murphy CJ, Russell P

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The effect of needle gauge, needle type, and needle orientation on the volume of a drop.

Vet Ophthalmol. 2015 Jan 27;

Authors: Tripp GK, Good KL, Motta MJ, Kass PH, Murphy CJ

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Quantitative Determination of Ligand Densities on Nanomaterials by X-ray Photoelectron Spectroscopy.

ACS Appl Mater Interfaces. 2015 Jan 15;

Authors: Torelli MD, Putans RA, Tan Y, Lohse SE, Murphy CJ, Hamers RJ

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KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis.

Nat Commun. 2015;6:8532

Authors: Nakajima K, Zhu K, Sun YH, Hegyi B, Zeng Q, Murphy CJ, Small JV, Chen-Izu Y, Izumiya Y, Penninger JM, Zhao M

2014

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Biomimetic stochastic topography and electric fields synergistically enhance directional migration of corneal epithelial cells in a MMP-3 dependent manner.

Acta Biomater. 2014 Oct 10;

Authors: Gao J, Raghunathan VK, Reid B, Wei D, Diaz RC, Russell P, Murphy CJ, Zhao M

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Impact of Nanotopography, Heparin Hydrogel Microstructures, and Encapsulated Fibroblasts on Phenotype of Primary Hepatocytes.

ACS Appl Mater Interfaces. 2014 Sep 23;

Authors: You J, Raghunathan VK, Son KJ, Patel D, Haque A, Murphy CJ, Revzin A

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Automated AFM force curve analysis for determining elastic modulus of biomaterials and biological samples.

J Mech Behav Biomed Mater. 2014 Sep;37C:209-218

Authors: Chang YR, Raghunathan VK, Garland SP, Morgan JT, Russell P, Murphy CJ

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Interfacial Phenomena and the Ocular Surface.

Ocul Surf. 2014 Jul;12(3):178-201

Authors: Yañez-Soto B, Mannis MJ, Schwab IR, Li JY, Leonard BC, Abbott NL, Murphy CJ

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The formation of cortical actin arrays in human trabecular meshwork cells in response to cytoskeletal disruption.

Exp Cell Res. 2014 Jun 30;

Authors: Murphy KC, Morgan JT, Wood JA, Sadeli A, Murphy CJ, Russell P

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Spectral domain optical coherence tomography imaging of spectacular ecdysis in the royal python (Python regius).

Vet Ophthalmol. 2014 May 14;

Authors: Tusler CA, Maggs DJ, Kass PH, Paul-Murphy JR, Schwab IR, Murphy CJ

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Full-thickness splinted skin wound healing models in db/db and heterozygous mice: Implications for wound healing impairment.

Wound Repair Regen. 2014 May;22(3):368-80

Authors: Park SA, Teixeira LB, Raghunathan VK, Covert J, Dubielzig RR, Isseroff RR, Schurr M, Abbott NL, McAnulty J, Murphy CJ

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Gross, histologic, and micro-computed tomographic anatomy of the lacrimal system of snakes.

Vet Ophthalmol. 2014 May 26;

Authors: Souza NM, Maggs DJ, Park SA, Puchalski SM, Reilly CM, Paul-Murphy J, Murphy CJ

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Anchoring a cytoactive factor in a wound bed promotes healing.

J Tissue Eng Regen Med. 2014 Mar 27;

Authors: Chattopadhyay S, Guthrie KM, Teixeira L, Murphy CJ, Dubielzig RR, McAnulty JF, Raines RT

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Reduction in Wound Bioburden using a Silver-Loaded Dissolvable Microfilm Construct.

Adv Healthc Mater. 2014 Feb 12;

Authors: Herron M, Agarwal A, Kierski PR, Calderon DF, Teixeira LB, Schurr MJ, Murphy CJ, Czuprynski CJ, McAnulty JF, Abbott NL

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A Cell Culture Substrate with Biologically Relevant Size-Scale Topography and Compliance of the Basement Membrane.

Langmuir. 2014 Feb 21;

Authors: Garland SP, McKee CT, Chang YR, Raghunathan VK, Russell P, Murphy CJ

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Photopatternable and photoactive hydrogel for on-demand generation of hydrogen peroxide in cell culture.

Biomaterials. 2014 Feb;35(5):1762-70

Authors: Garland SP, Wang RY, Raghunathan VK, Lam KS, Murphy CJ, Russell P, Sun G, Pan T

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Epidermal Growth Factor-Functionalized Polymeric Multilayer Films: Interplay between Spatial Location and Bioavailability of EGF.

J Invest Dermatol. 2014 Jan 3;

Authors: Gorouhi F, Shah NM, Krishna Raghunathan V, Mohabbati Y, Abbott NL, Isseroff RR, Murphy CJ

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Robust and artifact-free mounting of tissue samples for atomic force microscopy.

Biotechniques. 2014 Jan;56(1):40-2

Authors: Morgan JT, Raghunathan VK, Thomasy SM, Murphy CJ, Russell P

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Human Trabecular Meshwork Cells Exhibit Several Characteristics of, but Are Distinct from, Adipose-Derived Mesenchymal Stem Cells.

J Ocul Pharmacol Ther. 2014 Jan 23;

Authors: Morgan JT, Wood JA, Walker NJ, Raghunathan VK, Borjesson DL, Murphy CJ, Russell P

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PDGF-BB Does Not Accelerate Healing in Diabetic Mice with Splinted Skin Wounds.

PLoS One. 2014;9(8):e104447

Authors: Park SA, Raghunathan VK, Shah NM, Teixeira L, Motta MJ, Covert J, Dubielzig R, Schurr M, Isseroff RR, Abbott NL, McAnulty J, Murphy CJ

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Involvement of YAP, TAZ and HSP90 in Contact Guidance and Intercellular Junction Formation in Corneal Epithelial Cells.

PLoS One. 2014;9(10):e109811

Authors: Raghunathan VK, Dreier B, Morgan JT, Tuyen BC, Rose BW, Reilly CM, Russell P, Murphy CJ

2013

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Characterizing the effects of heparin gel stiffness on function of primary hepatocytes.

Tissue Eng Part A. 2013 Dec;19(23-24):2655-63

Authors: You J, Park SA, Shin DS, Patel D, Raghunathan VK, Kim M, Murphy CJ, Tae G, Revzin A

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The influence of substrate topography on the migration of corneal epithelial wound borders.

Biomaterials. 2013 Dec;34(37):9244-51

Authors: Yanez-Soto B, Liliensiek SJ, Gasiorowski JZ, Murphy CJ, Nealey PF

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Elastic modulus and collagen organization of the rabbit cornea: epithelium to endothelium.

Acta Biomater. 2013 Sep 28;

Authors: Thomasy SM, Raghunathan VK, Winkler M, Reilly CM, Sadeli AR, Russell P, Jester JV, Murphy CJ

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Safety and immunomodulatory effects of allogeneic canine adipose-derived mesenchymal stromal cells transplanted into the region of the lacrimal gland, the gland of the third eyelid and the knee joint.

Cytotherapy. 2013 Aug 29;

Authors: Park SA, Reilly CM, Wood JA, Chung DJ, Carrade DD, Deremer SL, Seraphin RL, Clark KC, Zwingenberger AL, Borjesson DL, Hayashi K, Russell P, Murphy CJ

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Substratum Compliance Modulates Corneal Fibroblast to Myofibroblast Transformation.

Invest Ophthalmol Vis Sci. 2013 Jul 16;

Authors: Dreier B, Thomasy SM, Mendonsa R, Raghunathan VK, Russell P, Murphy CJ

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What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease.

Exp Eye Res. 2013 Jun 20;

Authors: Morgan JT, Murphy CJ, Russell P

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Early responses of vascular endothelial cells to topographic cues.

Am J Physiol Cell Physiol. 2013 May 22;

Authors: Dreier B, Gasiorowski JZ, Morgan JT, Nealey PF, Russell P, Murphy CJ

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Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells.

Exp Eye Res. 2013 May 29;113C:66-73

Authors: Thomasy SM, Morgan JT, Wood JA, Murphy CJ, Russell P

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Tryptophan Inhibits Biofilm Formation by Pseudomonas aeruginosa.

Antimicrob Agents Chemother. 2013 Apr;57(4):1921-1925

Authors: Brandenburg KS, Rodriguez KJ, McAnulty JF, Murphy CJ, Abbott NL, Schurr MJ, Czuprynski CJ

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Integration of Silver Nanoparticle-impregnated Polyelectrolyte Multilayers Into Murine Splinted Cutaneous Wound Beds.

J Burn Care Res. 2013 Mar 18;

Authors: Guthrie KM, Agarwal A, Teixeira LB, Dubielzig RR, Abbott NL, Murphy CJ, Singh H, McAnulty JF, Schurr MJ

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Influence of extracellular matrix proteins and substratum topography on corneal epithelial cell alignment and migration.

Tissue Eng Part A. 2013 Mar 14;

Authors: Raghunathan V, McKee CT, Cheung W, Naik R, Nealey PF, Russell P, Murphy CJ

2012

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Biochemically and topographically engineered poly(ethylene glycol) diacrylate hydrogels with biomimetic characteristics as substrates for human corneal epithelial cells.

J Biomed Mater Res A. 2012 Dec 18;

Authors: Yañez-Soto B, Liliensiek SJ, Murphy CJ, Nealey PF

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Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ.

Invest Ophthalmol Vis Sci. 2012 Dec 20;

Authors: Raghunathan VK, Morgan JT, Dreier B, Reilly CM, Thomasy SM, Wood JA, Ly I, Tuyen BC, Hughbanks M, Murphy CJ, Russell P

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The use of native chemical functional groups presented by wound beds for the covalent attachment of polymeric microcarriers of bioactive factors.

Biomaterials. 2012 Oct 19;

Authors: Jain R, Agarwal A, Kierski PR, Schurr MJ, Murphy CJ, McAnulty JF, Abbott NL

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Polymeric multilayers that localize the release of chlorhexidine from biologic wound dressings.

Biomaterials. 2012 Oct;33(28):6783-92

Authors: Agarwal A, Nelson TB, Kierski PR, Schurr MJ, Murphy CJ, Czuprynski CJ, McAnulty JF, Abbott NL

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The influence of biomimetic topographical features and the extracellular matrix peptide RGD on human corneal epithelial contact guidance.

Acta Biomater. 2012 Oct 13;

Authors: Tocce EJ, Liliensiek SJ, Broderick AH, Jiang Y, Murphy KC, Murphy CJ, Lynn DM, Nealey PF

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Nuclear and cellular alignment of primary corneal epithelial cells on topography.

J Biomed Mater Res A. 2012 Sep 11;

Authors: Raghunathan VK, McKee CT, Tocce EJ, Nealey PF, Russell P, Murphy CJ

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The modulation of canine mesenchymal stem cells by nano-topographic cues.

Exp Cell Res. 2012 Jul 4;

Authors: Wood JA, Ly I, Borjesson DL, Nealey PF, Russell P, Murphy CJ

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Focal adhesion kinase knockdown modulates the response of human corneal epithelial cells to topographic cues.

Acta Biomater. 2012 Jul 17;

Authors: Dreier B, Raghunathan V, Russell P, Murphy CJ

Integration of basal topographic cues and apical shear stress in vascular endothelial cells.

Biomaterials. 2012 Jun;33(16):4126-35

Authors: Morgan JT, Wood JA, Shah NM, Hughbanks ML, Russell P, Barakat AI, Murphy CJ

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Antibacterial Efficacy of Silver-Impregnated Polyelectrolyte Multilayers Immobilized on a Biological Dressing in a Murine Wound Infection Model.

Ann Surg. 2012 May 17;

Authors: Guthrie KM, Agarwal A, Tackes DS, Johnson KW, Abbott NL, Murphy CJ, Czuprynski CJ, Kierski PR, Schurr MJ, McAnulty JF

Peptides that anneal to natural collagen in vitro and ex vivo.

Org Biomol Chem. 2012 Apr 23;

Authors: Chattopadhyay S, Murphy CJ, McAnulty JF, Raines RT

The influence of a biologically relevant substratum topography on human aortic and umbilical vein endothelial cells.

Biophys J. 2012 Mar 7;102(5):1224-33

Authors: McKee CT, Wood JA, Ly I, Russell P, Murphy CJ

Compliance profile of the human cornea as measured by atomic force microscopy.

Micron. 2012 Feb 25;

Authors: Last JA, Thomasy SM, Croasdale CR, Russell P, Murphy CJ

Functional and anatomic consequences of subretinal dosing in the cynomolgus macaque.

Arch Ophthalmol. 2012 Jan;130(1):65-75

Authors: Nork TM, Murphy CJ, Kim CB, Ver Hoeve JN, Rasmussen CA, Miller PE, Wabers HD, Neider MW, Dubielzig RR, McCulloh RJ, Christian BJ

 

Functionalization of reactive polymer multilayers with RGD and an antifouling motif: RGD density provides control over human corneal epithelial cell-substrate interactions.

J Biomed Mater Res A. 2012 Jan;100(1):84-93

Authors: Tocce EJ, Broderick AH, Murphy KC, Liliensiek SJ, Murphy CJ, Lynn DM, Nealey PF

Modulation of osteogenic differentiation in hMSCs cells by submicron topographically-patterned ridges and grooves.

Biomaterials. 2012 Jan;33(1):128-36

Authors: Watari S, Hayashi K, Wood JA, Russell P, Nealey PF, Murphy CJ, Genetos DC

Substratum topography modulates corneal fibroblast to myofibroblast transformation.

Invest Ophthalmol Vis Sci. 2012;53(2):811-6

Authors: Myrna KE, Mendonsa R, Russell P, Pot SA, Liliensiek SJ, Jester JV, Nealey PF, Brown D, Murphy CJ

Substratum stiffness and latrunculin B regulate matrix gene and protein expression in human trabecular meshwork cells.

Invest Ophthalmol Vis Sci. 2012;53(2):952-8

Authors: Thomasy SM, Wood JA, Kass PH, Murphy CJ, Russell P

Altered Stability of mRNAs Associated with Glaucoma Progression in Human Trabecular Meshwork Cells Following Oxidative Stress.

Invest Ophthalmol Vis Sci. 2012;53(4):1734-41

Authors: Mochizuki H, Murphy CJ, Brandt JD, Kiuchi Y, Russell P

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Hydrogels with well-defined peptide-hydrogel spacing and concentration: impact on epithelial cell behavior().

Soft Matter. 2012;8(2):390-398

Authors: Wilson MJ, Liliensiek SJ, Murphy CJ, Murphy WL, Nealey PF

2011

Periocular and Intra-Articular Injection of Canine Adipose-Derived Mesenchymal Stem Cells: An In Vivo Imaging and Migration Study.

J Ocul Pharmacol Ther. 2011 Dec 16;

Authors: Wood JA, Chung DJ, Park SA, Zwingenberger AL, Reilly CM, Ly I, Walker NJ, Vernau W, Hayashi K, Wisner ER, Cannon MS, Kass PH, Cherry SR, Borjesson DL, Russell P, Murphy CJ

Topographic modulation of the orientation and shape of cell nuclei and their influence on the measured elastic modulus of epithelial cells.

Biophys J. 2011 Nov 2;101(9):2139-46

Authors: McKee CT, Raghunathan VK, Nealey PF, Russell P, Murphy CJ

The role of substratum compliance of hydrogels on vascular endothelial cell behavior.

Biomaterials. 2011 Aug;32(22):5056-64

Authors: Wood JA, Shah NM, McKee CT, Hughbanks ML, Liliensiek SJ, Russell P, Murphy CJ

Indentation versus tensile measurements of Young's modulus for soft biological tissues.

Tissue Eng Part B Rev. 2011 Jun;17(3):155-64

Authors: McKee CT, Last JA, Russell P, Murphy CJ

Endotoxin-induced structural transformations in liquid crystalline droplets.

Science. 2011 Jun 10;332(6035):1297-300

Authors: Lin IH, Miller DS, Bertics PJ, Murphy CJ, de Pablo JJ, Abbott NL

The pharmacologic assessment of a novel lymphocyte function-associated antigen-1 antagonist (SAR 1118) for the treatment of keratoconjunctivitis sicca in dogs.

Invest Ophthalmol Vis Sci. 2011 May;52(6):3174-80

Authors: Murphy CJ, Bentley E, Miller PE, McIntyre K, Leatherberry G, Dubielzig R, Giuliano E, Moore CP, Phillips TE, Smith PB, Prescott E, Miller JM, Thomas P, Scagliotti R, Esson D, Gadek T, O'Neill CA

Elastic modulus determination of normal and glaucomatous human trabecular meshwork.

Invest Ophthalmol Vis Sci. 2011 Apr;52(5):2147-52

Authors: Last JA, Pan T, Ding Y, Reilly CM, Keller K, Acott TS, Fautsch MP, Murphy CJ, Russell P

The effect of biophysical attributes of the ocular trabecular meshwork associated with glaucoma on the cell response to therapeutic agents.

Biomaterials. 2011 Mar;32(9):2417-23

Authors: McKee CT, Wood JA, Shah NM, Fischer ME, Reilly CM, Murphy CJ, Russell P

Evaluation of therapeutic interventions for vaccinia virus keratitis.

J Infect Dis. 2011 Mar 1;203(5):683-90

Authors: Altmann S, Brandt CR, Murphy CJ, Patnaikuni R, Takla T, Toomey M, Nesbit B, McIntyre K, Covert J, Dubielzig R, Leatherberry G, Adkins E, Kodihalli S

 

Ocular components in three breeds of dogs with high prevalence of myopia.

Optom Vis Sci. 2011 Feb;88(2):269-74

Authors: Williams LA, Kubai MA, Murphy CJ, Mutti DO

Substratum compliance regulates human trabecular meshwork cell behaviors and response to latrunculin B.

Invest Ophthalmol Vis Sci. 2011;52(13):9298-303

Authors: Wood JA, McKee CT, Thomasy SM, Fischer ME, Shah NM, Murphy CJ, Russell P

2010

Alterations in gene expression of human vascular endothelial cells associated with nanotopographic cues.

Biomaterials. 2010 Dec;31(34):8882-8

Authors: Gasiorowski JZ, Liliensiek SJ, Russell P, Stephan DA, Nealey PF, Murphy CJ

The applications of atomic force microscopy to vision science.

Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6083-94

Authors: Last JA, Russell P, Nealey PF, Murphy CJ

Kinetics of immune cell infiltration in vaccinia virus keratitis.

Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4541-8

Authors: Altmann S, Toomey M, Nesbit B, McIntyre K, Covert J, Dubielzig RR, Leatherberry G, Adkins E, Murphy CJ, Brandt CR

Biosynthetic corneal substitute implantation in dogs.

Cornea. 2010 Aug;29(8):910-6

Authors: Bentley E, Murphy CJ, Li F, Carlsson DJ, Griffith M

Modulation of human vascular endothelial cell behaviors by nanotopographic cues.

Biomaterials. 2010 Jul;31(20):5418-26

Authors: Liliensiek SJ, Wood JA, Yong J, Auerbach R, Nealey PF, Murphy CJ

The ability of corneal epithelial cells to recognize high aspect ratio nanostructures.

Biomaterials. 2010 May;31(14):4064-72

Authors: Tocce EJ, Smirnov VK, Kibalov DS, Liliensiek SJ, Murphy CJ, Nealey PF

Surfaces modified with nanometer-thick silver-impregnated polymeric films that kill bacteria but support growth of mammalian cells.

Biomaterials. 2010 Feb;31(4):680-90

Authors: Agarwal A, Weis TL, Schurr MJ, Faith NG, Czuprynski CJ, McAnulty JF, Murphy CJ, Abbott NL

The PPCD1 mouse: characterization of a mouse model for posterior polymorphous corneal dystrophy and identification of a candidate gene.

PLoS One. 2010;5(8):e12213

Authors: Shen AL, O'Leary KA, Dubielzig RR, Drinkwater N, Murphy CJ, Kasper CB, Bradfield CA