Dr. Ver Hoeve is Senior Scientist and Director of Electrodiagnostic Services in the Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health. He is responsible for electroretinographic and visual evoked potential testing in human patients and has conducted research in numerous animal models. He is currently investigating neuroprotection strategies in a non-human primate model of experimental glaucoma.
Localized retinal manifestations of paraneoplastic autoimmune retinopathy.
Retin Cases Brief Rep. 2014;8(4):318-21
Authors: Eadie JA, Ip MS, Ver Hoeve JN
PURPOSE: Systemic neoplastic processes can affect the retina through autoimmune retinopathy. This process may present in a variety of patterns. A novel pattern of paraneoplastic autoimmune retinopathy has been described.
METHODS: Two patients presented with paraneoplastic vision changes. Optical coherence tomography and multifocal electroretinography were performed, which showed a unique focal retinal change in both patients. Case 1 is a 20-year-old woman with history of cutaneous melanoma. Case 2 is 67-year-old woman with history of breast cancer.
RESULTS: Both patients showed a localized area of foveal thinning that corresponded with areas of depression on multifocal electroretinography. Each tested positive for antiretinal antibodies.
CONCLUSION: This is a novel manifestation of paraneoplastic autoimmune retinopathy. Previously described cases have all affected the retina diffusely. These cases highlight the need to consider distant neoplastic processes when evaluating patient with similar presentations to those depicted here.
PMID: 25372537 [PubMed - in process]
Spontaneous optic nerve compression in the osteopetrotic (op/op) mouse: a novel model of myelination failure.
J Neurosci. 2013 Feb 20;33(8):3514-25
Authors: Kondo Y, Ramaker JM, Radcliff AB, Baldassari S, Mayer JA, Ver Hoeve JN, Zhang CL, Chiu SY, Colello RJ, Duncan ID
We report a focal disturbance in myelination of the optic nerve in the osteopetrotic (op/op) mouse, which results from a spontaneous compression of the nerve resulting from stenosis of the optic canal. The growth of the op/op optic nerve was significantly affected, being maximally suppressed at postnatal day 30 (P30; 33% of age matched control). Myelination of the nerve in the optic canal was significantly delayed at P15, and myelin was almost completely absent at P30. The size of nerves and myelination were conserved both in the intracranial and intraorbital segments at P30, suggesting that the axons in the compressed site are spared in all animals at P30. Interestingly, we observed recovery both in the nerve size and the density of myelinated axons at 7 months in almost half of the optic nerves examined, although some nerves lost axons and became atrophic. In vivo and ex vivo electrophysiological examinations of P30 op/op mice showed that nerve conduction was significantly delayed but not blocked with partial recovery in some mice by 7 months. Transcardial perfusion of FITC-labeled albumin suggested that local ischemia was at least in part the cause of this myelination failure. These results suggest that the primary abnormality is dysmyelination of the optic nerve in early development. This noninvasive model system will be a valuable tool to study the effects of nerve compression on the function and survival of oligodendrocyte progenitor cells/oligodendrocytes and axons and to explore the mechanism of redistribution of oligodendrocyte progenitor cells with compensatory myelination.
PMID: 23426679 [PubMed - indexed for MEDLINE]