Gender differences in iridocorneal angle morphology: a potential explanation for the female predisposition to primary angle closure glaucoma in dogs

Vet Ophthalmol. 2012 Mar;15 Suppl 1:60-3. doi: 10.1111/j.1463-5224.2011.00956.x. Epub 2011 Oct 17.

ABSTRACT

OBJECTIVE: Female dogs have approximately twice the risk of males for developing primary angle closure glaucoma (PACG). The cause of this gender difference is unknown, but one theory proposes that the gender differences in iridocorneal angle morphology are involved in this risk differential.

PROCEDURES: Fifty beagles (25 males, 25 females) were included into this study and had normal baseline ophthalmic examinations. Normal dogs were selected so as to avoid any potentially confounding influence of goniodysgenesis. Standardized 20-MHz high-resolution ultrasound images of the iridocorneal angle were acquired from one eye of each dog with the scan plane perpendicular to the limbus in the superior temporal quadrant. Images were imported into ImageJ, and the angle opening distance (AOD) and angle recess area (ARA) were measured by a masked observer, and the analysis of variance method was used to compare differences.

RESULTS: The mean (±SD) AOD was significantly smaller for female dogs (0.847 ± 0.241 mm) vs. male dogs (1.058 ± 0.322 mm) P-value = 0.012. The mean (± SD) ARA tended to be smaller for female dogs (0.584 ± 0.278 mm) vs. male dogs (0.748 ± 0.385 mm), but this difference was not significant (P-value = 0.092).

CONCLUSIONS: Female dogs have a significantly smaller AOD vs. males. This difference may render the female iridocorneal angle more susceptible to closure and may partially explain the 2:1 female/male predisposition to PACG. Further studies using goniodysgenic dogs are warranted.

PMID:22050644 | DOI:10.1111/j.1463-5224.2011.00956.x

Description

CONCLUSIONS: Female dogs have a significantly smaller AOD vs. males. This difference may render the female iridocorneal angle more susceptible to closure and may partially explain the 2:1 female/male predisposition to PACG. Further studies using goniodysgenic dogs are warranted.

pubmed:22050644
https://pubmed.ncbi.nlm.nih.gov/22050644/?utm_source=curl&utm_medium=rss&utm_campaign=None&utm_content=1bk4uPJPP8lzd5CTyn_YnZ8rN0DZNEMtCKvKGU_JJLi5xB29hZ&fc=None&ff=20230627173853&v=2.17.9.post6+86293ac
Published Date
2011-11-05
Associated Team Member
Vet Ophthalmol
Feed Publication Page
15 Suppl 1:60-3
2011
11
Susan Tsai, Ellison Bentley, Paul E Miller, Filipe E Gomes, Chang Vangyi, Anne Wiese, Alexandra Almazan, Huajiang Li, Paul Conforti, Susan S Lee, Michael R Robinson
Investigation Type
Development Phase