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The majority of our work involves studies that support the development of new ocular therapies and devices.  We have also participated in investigative studies that have advanced the field of preclinical development.  You may also filter for Development phase, (e.g., Safety) ophthalmology discipline (e.g., ocular imaging) and therapeutic class (e.g., Gene and Cell therapies).

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Investigation Type Development Phase Therapy Class Discipline(s)
Susvimo
EVALUATION OF SURGICAL FACTORS AFFECTING VITREOUS HEMORRHAGE FOLLOWING PORT DELIVERY SYSTEM WITH RANIBIZUMAB IMPLANT INSERTION IN A MINIPIG MODEL 		Approved Therapy Investigative Port Delivery System Implant
  • Ocular Surgery
 Detail

Susvimo
EVALUATION OF SURGICAL FACTORS AFFECTING VITREOUS HEMORRHAGE FOLLOWING PORT DELIVERY SYSTEM WITH RANIBIZUMAB IMPLANT INSERTION IN A MINIPIG MODEL

Retina. 2020 Aug;40(8):1520-1528. doi: 10.1097/IAE.0000000000002614.

ABSTRACT

PURPOSE: To develop an animal model of vitreous hemorrhage (VH) to explore the impact of surgical parameters on VH associated with insertion of the Port Delivery System with ranibizumab (PDS) implant.

METHODS: Ninety eyes from 45 treatment-naive male Yucatan minipigs received PDS implant insertion or a sham procedure. The effect of prophylactic pars plana hemostasis, scleral incision length, scleral cauterization, surgical blade type/size, and viscoelastic usage on postsurgical VH was investigated.

RESULTS: Postsurgical VH was detected in 60.0% (54/90) of implanted eyes. A systematic effect on VH was only detected for pars plana hemostasis before the pars plana incision. The percentage of eyes with VH was 96.6% (28/29) among eyes that did not receive prophylactic pars plana hemostasis and 42.4% (24/58) among eyes that did. There was no VH in eyes that received laser ablation of the pars plana using overlapping 1,000-ms spots; pars plana cautery or diathermy was less effective. The majority of all VH cases (83.3% [45/54]) were of mild to moderate severity (involving ≤25% of the fundus).

CONCLUSION: In this minipig surgical model of VH, scleral dissection followed by pars plana laser ablation before pars plana incision most effectively mitigated VH secondary to PDS implant insertion.

PMID:31436674 | PMC:PMC7392584 | DOI:10.1097/IAE.0000000000002614

Publication Authors
Vladimir Bantseev, Chris Schuetz, Helen S Booler, Joshua Horvath, Kristof Hovaten, Signe Erickson, Ellison Bentley, T Michael Nork, William R Freeman, Jay M Stewart, Giulio Barteselli
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