Publication Reference Index

The majority of our work involves studies that support the development of new ocular therapies and devices.  We have also participated in investigative studies that have advanced the field of preclinical development.  You may also filter for Development phase, (e.g., Safety) ophthalmology discipline (e.g., ocular imaging) and therapeutic class (e.g., Gene and Cell therapies).

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Investigation Type Development Phase Therapy Class Discipline(s)
VEP and PERG acuity in anesthetized young adult rhesus monkeys Advancing the Field Safety
  • Electrodiagnostics
Detail
Swelling and loss of photoreceptors in chronic human and experimental glaucomas Advancing the Field Pharmacology
  • Electrodiagnostics
Detail
Lucentis
Safety Evaluation of Intravitreal Administration of rhuFab VEGF in Cynomolgus Monkeys for 3 Months
Approved Therapy Safety Fab Protein
  • Ophthalmic Exam
  • Electrodiagnostics
  • Ocular Imaging
Detail
Determination of the neuroprotective effects of hsp-27 and PC3-96 against ischemic insult. Advancing the Field Investigative Heat Shock Protein 27
  • In Vitro
Detail
Lucentis
Safety Evaluation of Differing Schedules of Intravitreal Administration of rhuFab VEGF in Cynomolgus Monkeys for 2 Months
Approved Therapy Safety Fab Protein
  • Ophthalmic Exam
  • Electrodiagnostics
  • Ocular Imaging
Detail
Lucentis
Characterization of a Monkey Model of Laser-Induced Choroidal Neovascularization (CNV)
Approved Therapy Safety Fab Protein
  • Ocular Imaging
Detail
Lucentis
26-Week Intravitreal Injection Toxicity Study with rhuFab VEGF in Cynomolgus Monkeys with an 8-Week Recovery
Approved Therapy Safety Fab Protein
  • Ophthalmic Exam
  • Electrodiagnostics
  • Ocular Imaging
Detail
Evaluation of intra-and interobserver reliability and image reproducibility to assess usefulness of high-resolution ultrasonography for measurement of anterior segment structures of canine eyes Advancing the Field Investigative
  • Ocular Imaging
Detail
Eylea
Pharmacokinetics and ocular tissue penetration of VEGF Trap after intravitreal injections in rabbits
Approved Therapy Pharmacokinetics Fusion Protein
  • Ocular Pharmacology
Detail
Multifocal visual evoked potentials in the anesthetized non-human primate Advancing the Field Safety
  • Electrodiagnostics
Detail
Measurement of regional choroidal blood flow in rabbits and monkeys using fluorescent microspheres Advancing the Field Investigative
  • Ocular Dosing
Detail
Eylea
Safety evaluation of intravitreal administration of VEGF trap in cynomolgus monkeys for 13 weeks.
Approved Therapy Safety Fusion Protein
  • Ophthalmic Exam
  • Electrodiagnostics
  • Ocular Imaging
Detail
Bimatoprost, prostamide activity, and conventional drainage Therapy Development Investigative Prostaglandin
  • Ophthalmic Exam
Detail
Evaluation of EIAV Based Lentiviral Vectors Following Ocular Delivery in the Nonhuman Primate Model: Development of RetinoStat® Therapy Development Safety Gene and Cell
  • Ophthalmic Exam
  • Electrodiagnostics
  • Ocular Imaging
Detail
Pachymetry in New Zealand White Rabbits, Beagle Dogs, and Cynomolgus Monkeys. Advancing the Field Safety
  • Ophthalmic Exam
Detail
Corneal endothelial cell density measurements using noncontact specular microscopy in rabbits, dogs and monkeys Advancing the Field Safety
  • Ocular Imaging
Detail
Standardized Full-Field Electroretinography in Cynomolgus Monkeys Advancing the Field Safety
  • Electrodiagnostics
Detail
Ocular and systemic safety evaluation of calcium formate as a dietary supplement Therapy Development Clinical Trial Small Molecue
  • Electrodiagnostics
Detail
Retinal effects of 6 months of daily use of tadalafil or sildenafil Therapy Development Clinical Trial Small Molecue
  • Ocular Imaging
Detail
Bilateral optic atrophy: a background finding in cynomolgus macaques used in toxicologic research Advancing the Field Safety
  • Ocular Imaging
Detail
Continuous Monitoring of Intraocular Pressure in New Zealand White Rabbits Using Telemetry Advancing the Field Pharmacology
  • Ocular Surgery
Detail
Ocular inflammation in cynomolgus macaques following intravenous administration of a human monoclonal antibody Therapy Development Safety Monoclonal Antibodies
  • Ophthalmic Exam
Detail
Lucentis
Prevention of Laser Photocoagulation Induced Choroidal Neovascularization Lesions by Intravitreal Doses of Ranibizumab in Cynomolgus Monkeys
Approved Therapy Pharmacology Fab Protein
  • Ocular Imaging
Detail
Serial multifocal electroretinograms during long-term elevation and reduction of intraocular pressure in non-human primates Advancing the Field Safety
  • Electrodiagnostics
Detail
Xiidra
Delivery of SAR 1118 to the retina via ophthalmic drops and its effectiveness in a rat streptozotocin (STZ) model of diabetic retinopathy (DR)
Approved Therapy Pharmacology Protein Detail
Relative contribution of VEGF and TNF-alpha in the cynomolgus laser-induced CNV model: comparing the efficacy of bevacizumab, adalimumab, and ESBA105 Advancing the Field Pharmacology
  • Ocular Imaging
Detail
Supplemental Clock-Hour Fluorescein Angiography (FA) Scoring and Image Analysis of Laser-Induced Choroidal Neovascularization (CNV) Lesions in Cynomolgus Monkeys Advancing the Field Pharmacology
  • Ocular Imaging
Detail
INO-8875, an adenosine A1 agonist, lowers intraocular pressure through the conventional outflow pathway Therapy Development Investigative Small Molecue, Adensine Receptor Agonist
  • Ophthalmic Exam
Detail
Spectral domain OCT segmentation accuracy in monkeys Advancing the Field Safety
  • Ocular Imaging
Detail
Gender differences in iridocorneal angle morphology: a potential explanation for the female predisposition to primary angle closure glaucoma in dogs Advancing the Field Investigative
  • Ocular Imaging
Detail