Optic Nerve/Retinal Nerve Fiber Layer

OSOD has experience with and access to both of the following instruments, if needed, for assessing the optic nerve/retinal nerve fiber layer.

Scanning Laser Polarimetry (GDxVCC, GDxECC)

This instrument provides a measurement of the retinal nerve fiber layer (RNFL) based on its birefringence, or change in angle of polarized light. Changes in polarization (retardance) are correlated with changes in RNFL thickness, although disruption of microtubules within axons may also alter polarimetric measures. GDx polarimetry measurements, with enhanced corneal compensation, are used in glaucoma research and are feasible in pre-clinical development.

Heidelberg Retina Tomograph (HRT)

This instrument is a confocal laser scanning system that creates a 3-D surface map (topography) of the retinal surface from the change in reflectance in a series of 2-D scans. Confocal scanning laser ophthalmoscopy is used to measure the surface configuration of the retinal nerve fiber layer, and various parameters of the optic nerve head and also to identify and track progression of changes in the eye due to glaucoma.