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Yelena Krakova

Vision Scientist
Accreditations
BS
MS
Disciplines
Electrodiagnostics
Optical Coherence Tomography

 

Yelena Krakova is a vision scientist, currently working on the project management team at OSOD. With a Master's degree in Biomedical Engineering, and a neural engineering focus, Ms. Krakova brings a unique perspective to vision science, leveraging her technical expertise to develop innovative solutions for preclinical research and drug development. Prior to joining OSOD, Ms. Krakova's focused on electrophysiology and ocular toxicology, undertaking graduate research in a neural engineering vision laboratory to help pioneer the development and testing of a novel product for the research and diagnosis of retinal diseases. She has 16 years of laboratory experience and 6 years of experience at OSOD and provides support for the development and implementation of technical services, equipment maintenance, staff development and data services. Yelena transitioned into project management and assists in facilitating the advancement of external client challenges while accelerating their product development.

Recent Publications

2020

Ocular distribution and efficacy after suprachoroidal injection of AU-011 for treatment of ocular melanoma

Investigative Ophthalmology & Visual Science, 61(7), pp.3615-3615

Savinainen, A., Grossniklaus, H., Kang, S., Rasmussen, C., Bentley, E., Krakova, Y., Struble, C.B. and Rich, C., 2020
Ocular distribution and efficacy after suprachoroidal injection of AU-011 for treatment of ocular melanoma
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2019

Normative Values for Multifocal ERGs Recorded from Cynomolgus Macaques in a Non-clinical Setting

In Investigative Ophthalmology & Visual Science (Vol. 60, No. 9)

Krakova, Y., Kim, C.B., Eaton, S., Christian, B.J., Budzynski, E., Miller, J., Nork, T.M., Murphy, C.J. and Ver Hoeve, J.N., 2019, July
Normative Values for Multifocal ERGs Recorded from Cynomolgus Macaques in a Non-clinical Setting
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2014

Spatial differences in corneal electroretinogram potentials measured in rat with a contact lens electrode array

Doc Ophthalmol. 2014 Dec;129(3):151-66. doi: 10.1007/s10633-014-9459-5. Epub 2014 Sep 30.

ABSTRACT

PURPOSE: It has been known for several decades that the magnitude of the corneal electroretinogram (ERG) varies with position on the eye surface, especially in the presence of focal or asymmetric stimuli or retinal lesions. However, this phenomenon has not been well-characterized using simultaneous measurements at multiple locations on the cornea. This work provides the first characterization of spatial differences in the ERG across the rat cornea.

METHODS: A contact lens electrode array was employed to record ERG potentials at 25 corneal locations simultaneously following brief full-field flash stimuli in normally sighted Long-Evans rats. These multi-electrode electroretinogram (meERG) responses were analyzed for spatial differences in a-wave and b-wave amplitudes and implicit times.

RESULTS: Spatially distinct ERG potentials could be recorded reliably. Comparing relative amplitudes across the corneal locations suggested a slight non-uniform distribution when using full-field, near-saturating stimuli. Amplitudes of a- and b-waves were approximately 3 % lower in the inferior quadrant than in the superior quadrant of the cornea.

CONCLUSIONS: The present results comprise the start of the first normative meERG database for rat eyes and provide a basis for comparison of results from eyes with functional deficit. Robust measures of spatial differences in corneal potentials will also support optimization and validation of computational source models of the ERG. To fully utilize the information contained in the meERG data, a detailed understanding of the roles of the many determinants of local corneal potentials will eventually be required.

PMID:25266461 | PMC:PMC4219023 | DOI:10.1007/s10633-014-9459-5

Full Publication
Yelena Krakova, Hadi Tajalli, Sanitta Thongpang, Zahra Derafshi, Tamas Ban, Safa Rahmani, Ashley N Selner, Amani Al-Tarouti, Justin C Williams, John R Hetling
Spatial differences in corneal electroretinogram potentials measured in rat with a contact lens electrode array
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