T. Michael Nork

Accreditations

Dr. Nork is a founder, serves as a member of the Executive Board, and provides consulting on many aspects of vision science.

Dr. Nork is an Associate Professor of Ophthalmology at the University of Wisconsin School of Medicine and Public Health. He is fellowship trained in ophthalmic pathology, and his clinical specialties include diseases, surgery of the retina and vitreous, and clinical electrophysiology.

His research model incorporates electrophysiologic and histopathologic techniques to assess the effects of glaucoma on the outer retina (the photoreceptors) and possible neuroprotective mechanisms. In collaboration with the University of Wisconsin Department of Ophthalmology Fundus Photograph Reading Center, Dr. Nork grades retina photographs and optical coherence tomographs for toxicologic studies. He also provides surgical expertise on vitrectomy, subretinal injections and retinal laser photocoagulation for animal models of choroidal neovascularization.

Recent Publications

2023

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus
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Multifocal electroretinography increases following experimental glaucoma in nonhuman primates with retinal ganglion cell axotomy
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2022

Accommodative movements of the choroid in the optic nerve head region of human eyes, and their relationship to the lens
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NONSURGICAL RESOLUTION OF FULL-THICKNESS MACULAR HOLES WITHOUT VITREOMACULAR TRACTION
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Intraocular accommodative movements in monkeys; relationship to presbyopia
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Effect of intraocular pressure (IOP), volume and location on the distribution of aqueous solutions injected into the suprachoroidal (SC) space
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2020

Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus
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Schwartz-Matsuo syndrome: An important cause of secondary glaucoma
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2019

EVALUATION OF SURGICAL FACTORS AFFECTING VITREOUS HEMORRHAGE FOLLOWING PORT DELIVERY SYSTEM WITH RANIBIZUMAB IMPLANT INSERTION IN A MINIPIG MODEL
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Determination of a No Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Cynomolgus Monkeys
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Normative Values for Multifocal ERGs Recorded from Cynomolgus Macaques in a Non-clinical Setting
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2018

Ocular Safety of AAV2. 7m8-ChrimsonR-tdTomato (GS030-DP) following intravitreous injection and exposure to 595 nm LED light in blind rd1 mice
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2017

Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model
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Effects of Vitrectomy and Lensectomy on Older Rhesus Macaques: Oxygen Distribution, Antioxidant Status, and Aqueous Humor Dynamics
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Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging
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Preliminary tolerability of iPSC-Derived RPE on PLGA scaffold implantation in RNU Nude Rats
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2016

Single ocular injection of a sustained-release anti-VEGF delivers 6months pharmacokinetics and efficacy in a primate laser CNV model
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Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia
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Safety and Biodistribution Evaluation in CNGB3-Deficient Mice of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia
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Toluene inhalation exposure for 13 weeks causes persistent changes in electroretinograms of Long-Evans rats
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Variability in the Electroretinographic Response of Laboratory Animals
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Cone-specific promoters for gene therapy of achromatopsia and other retinal diseases
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2015

Cone-Specific Promoters for Gene Therapy of Achromatopsia and Other Retinal Diseases
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Functional and Structural Effects of Subretinal Dose Delivery in Mice
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2014

Regional choroidal blood flow and multifocal electroretinography in experimental glaucoma in rhesus macaques
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Implications of retinal effects observed in chronic toxicity studies on the clinical development of a CNS-active drug candidate
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Gender Differences in Anesthetized Primate ERG and Full-field Flash VEP
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2013

Accommodative movements of the vitreous membrane, choroid, and sclera in young and presbyopic human and nonhuman primate eyes
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Structural and functional effects of hemiretinal endodiathermy axotomy in cynomolgus macaques
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Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals
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Inner Nuclear Layer (INL) Cystoid Spaces (Lacunae) Observed in Experimental Glaucoma and Axotomy in Non-Human Primates (NHPs)
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Emerging Electrophysiological Technologies for Assessing Ocular Toxicity in Laboratory Animals
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Electrophysiologic Correlates of RNFL Thickness in Experimental Glaucoma
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2012

Safety and biodistribution of an equine infectious anemia virus-based gene therapy, RetinoStat(®), for age-related macular degeneration
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Massive spontaneous suprachoroidal hemorrhage in a young woman with cystic fibrosis and diabetes mellitus on anticoagulants
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Structure/function studies and the effects of memantine in monkeys with experimental glaucoma
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AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, inhibits angiogenesis in models of ocular neovascular diseases
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Safety and biodistribution of an equine infectious anemia-based gene therapy, Retinostat®, for age-related macular degeneration
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AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, inhibits angiogenesis in models of ocular neovascular diseases
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2011

The effect of pentobarbital sodium and propofol anesthesia on multifocal electroretinograms in rhesus macaques
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Functional and anatomic consequences of subretinal dosing in the cynomolgus macaque
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Prevention of experimental choroidal neovascularization and resolution of active lesions by VEGF trap in nonhuman primates
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Subretinal Administration of Fluorescent Microspheres in the Minipig
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Safety And Tolerability Of Retinostat®, A Lentiviral-vector Based Gene Therapy Product For The Treatment Of Wet Age-related Macular Degeneration, In Rabbits And Monkeys
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Inter-ocular And Inter-subject Variability In The Full-field Electroretinograms Of Rabbits And Monkeys
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2010

Serial multifocal electroretinograms during long-term elevation and reduction of intraocular pressure in non-human primates
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Relative contribution of VEGF and TNF-alpha in the cynomolgus laser-induced CNV model: comparing the efficacy of bevacizumab, adalimumab, and ESBA105
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Supplemental Clock-Hour Fluorescein Angiography (FA) Scoring and Image Analysis of Laser-Induced Choroidal Neovascularization (CNV) Lesions in Cynomolgus Monkeys
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Spectral domain OCT segmentation accuracy in monkeys
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2009

Bilateral optic atrophy: a background finding in cynomolgus macaques used in toxicologic research
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Prevention of Laser Photocoagulation Induced Choroidal Neovascularization Lesions by Intravitreal Doses of Ranibizumab in Cynomolgus Monkeys
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2008

Evaluation of EIAV Based Lentiviral Vectors Following Ocular Delivery in the Nonhuman Primate Model: Development of RetinoStat®
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Standardized Full-Field Electroretinography in Cynomolgus Monkeys
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2006

Measurement of regional choroidal blood flow in rabbits and monkeys using fluorescent microspheres
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Safety evaluation of intravitreal administration of VEGF trap in cynomolgus monkeys for 13 weeks.
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2004

Interspecies and gender differences in multifocal electroretinograms of cynomolgus and rhesus macaques
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2003

Characterization of a Monkey Model of Laser-Induced Choroidal Neovascularization (CNV)
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26-Week Intravitreal Injection Toxicity Study with rhuFab VEGF in Cynomolgus Monkeys with an 8-Week Recovery
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2001

Safety Evaluation of Differing Schedules of Intravitreal Administration of rhuFab VEGF in Cynomolgus Monkeys for 2 Months
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2000

Swelling and loss of photoreceptors in chronic human and experimental glaucomas
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Safety Evaluation of Intravitreal Administration of rhuFab VEGF in Cynomolgus Monkeys for 3 Months
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