Simon Cherry

Accreditations

Dr. Cherry is Professor in the Department of Biomedical Engineering and Director of the Center for Molecular and Genomic Imaging at the University of California, Davis. Dr. Cherry’s research interests center around biomedical imaging and in particular the development and application of in vivo molecular imaging technology and systems, with specific expertise in positron emission tomography (PET) and optical imaging and their application in preclinical research. The technologies developed by his laboratory have been broadly applied in biomedical science to study disease processes and measure the effects of novel therapeutic interventions. Dr. Cherry is an elected fellow of five professional societies, including the Institute for Electronic and Electrical Engineers (IEEE) and the Biomedical Engineering Society (BMES). He is Editor-in-Chief of the journal Physics in Medicine and Biology. Dr. Cherry is the author of more than 200 peer-reviewed journal articles, review articles and book chapters in the field of biomedical imaging.

Recent Publications

2024

Optimization-derived blood input function using a kernel method and its evaluation with total-body PET for brain parametric imaging
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Non-invasive quantification of <sup>18</sup>F-florbetaben with total-body EXPLORER PET
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Dose Reduction in Pediatric Oncology Patients with Delayed Total-Body [<sup>18</sup>F]FDG PET/CT
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High-Temporal-Resolution Kinetic Modeling of Lung Tumors with Dual-Blood Input Function Using Total-Body Dynamic PET
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Super-resolution reconstruction of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mstyle><mml:mstyle><mml:mi>γ</mml:mi></mml:mstyle></mml:mstyle></mml:math>-ray CT images for PET-enabled dual-energy CT imaging
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Feasibility of PET-enabled dual-energy CT imaging: First physical phantom and patient results
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Development of a Monte Carlo-based scatter correction method for total-body PET using the uEXPLORER PET/CT scanner
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Non-invasive quantification of <sup>18</sup>F-florbetaben with total-body EXPLORER PET
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2023

Machine Learning in PET: from Photon Detection to Quantitative Image Reconstruction
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Practical Considerations for Total-Body PET Acquisition and Imaging
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Numerical investigation reveals challenges in measuring the contrast recovery coefficients in PET
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Total-body Dynamic Imaging and Kinetic Modeling of <sup>18</sup>F-AraG in Healthy Individuals and a Non-Small Cell Lung Cancer Patient Undergoing Anti-PD-1 Immunotherapy
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First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody
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Total-Body Positron Emission Tomography: Adding New Perspectives to Cardiovascular Research
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Total-Body Multiparametric PET Quantification of <sup>18</sup>F-FDG Delivery and Metabolism in the Study of Coronavirus Disease 2019 Recovery
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Colored reflectors to improve coincidence timing resolution of BGO-based time-of-flight PET detectors
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Total-Body Perfusion Imaging with [<sup>11</sup>C]-Butanol
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On timing-optimized SiPMs for Cherenkov detection to boost low cost time-of-flight PET
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Fully Automated, Fast Motion Correction of Dynamic Whole-Body and Total-Body PET/CT Imaging Studies
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Total-Body Multiparametric PET Quantification of <sup>18</sup> F-FDG Delivery and Metabolism in the Study of COVID-19 Recovery
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High-Temporal-Resolution Lung Kinetic Modeling Using Total-Body Dynamic PET with Time-Delay and Dispersion Corrections
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First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody
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Kinetic Evaluation of the Hypoxia Radiotracers [<sup>18</sup>F]FMISO and [<sup>18</sup>F]FAZA in Dogs with Spontaneous Tumors Using Dynamic PET/CT Imaging
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<sup>18</sup>F-FDG gallbladder uptake: observation from a total-body PET/CT scanner
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2022

Exploring Vessel Wall Biology In Vivo by Ultrasensitive Total-Body PET
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Lutetium background radiation in total-body PET-A simulation study on opportunities and challenges in PET attenuation correction
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Fully Automated, Semantic Segmentation of Whole-Body <sup>18</sup>F-FDG PET/CT Images Based on Data-Centric Artificial Intelligence
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Ultrafast timing enables reconstruction-free positron emission imaging
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Relating<sup>18</sup>F-FDG image signal-to-noise ratio to time-of-flight noise-equivalent count rate in total-body PET using the uEXPLORER scanner
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Total-Body <sup>18</sup>F-FDG PET/CT in Autoimmune Inflammatory Arthritis at Ultra-Low Dose: Initial Observations
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Blanching Defects at the Pressure Points: Observations from Dynamic Total-Body PET/CT Studies
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Total-body PET/CT - First Clinical Experiences and Future Perspectives
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2021

Efficient Delay Correction for Total-Body PET Kinetic Modeling Using Pulse Timing Methods
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Focus on early career researchers
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Total-Body PET Multiparametric Imaging of Cancer Using a Voxelwise Strategy of Compartmental Modeling
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Performance evaluation of dual-ended readout PET detectors based on BGO arrays with different reflector arrangements
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Quantitative accuracy in total-body imaging using the uEXPLORER PET/CT scanner
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Study of Čerenkov Light Emission in the Semiconductors TlBr and TlCl for TOF-PET
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Total-Body PET Kinetic Modeling and Potential Opportunities Using Deep Learning
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Compton PET: A Simulation Study for a PET Module with Novel Geometry and Machine Learning for Position Decoding
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Avalanche photodetectors with photon trapping structures for biomedical imaging applications
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New PET technologies - embracing progress and pushing the limits
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H<sup>2</sup>RSPET: a 0.5 mm resolution high-sensitivity small-animal PET scanner, a simulation study
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2020

Quantitative PET in the 2020s: a roadmap
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Energy and electron drift time measurements in a pixel CCI TlBr detector with 1.3 MeV prompt-gammas
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Cerenkov light transport in scintillation crystals explained: realistic simulation with GATE
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Phase 1 Trial of MLN0128 (Sapanisertib) and CB-839 HCl (Telaglenastat) in Patients With Advanced NSCLC (NCI 10327): Rationale and Study Design
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Scanner Design Considerations for Long Axial Field-of-View PET Systems
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Performance comparison of dual-ended readout depth-encoding PET detectors based on BGO and LYSO crystals
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Performance Evaluation of the uEXPLORER Total-Body PET/CT Scanner Based on NEMA NU 2-2018 with Additional Tests to Characterize PET Scanners with a Long Axial Field of View
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Total-Body Quantitative Parametric Imaging of Early Kinetics of <sup>18</sup>F-FDG
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The reduction of <sup>176</sup>Lu background in Lu-based PET scanners using optimized classification
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A depth-encoding PET detector for high resolution PET using 1 mm SiPMs
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A near-infrared probe for non-invasively monitoring cerebrospinal fluid flow by <sup>18</sup>F-positron emitting tomography and fluorescence
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Cerenkov luminescence and PET imaging of <sup>90</sup>Y: capabilities and limitations in small animal applications
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Subsecond total-body imaging using ultrasensitive positron emission tomography
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2019

Imaging Salt Uptake Dynamics in Plants Using PET
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Design and evaluation of gapless curved scintillator arrays for simultaneous high-resolution and high-sensitivity brain PET
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Total-Body PET and Highly Stable Chelators Together Enable Meaningful <sup>89</sup>Zr-Antibody PET Studies up to 30 Days After Injection
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First Cerenkov charge-induction (CCI) TlBr detector for TOF-PET and proton range verification
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Real-time whole-plant dynamics of heavy metal transport in <em>Arabidopsis halleri</em> and <em>Arabidopsis thaliana</em> by gamma-ray imaging
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Total-Body Dynamic Reconstruction and Parametric Imaging on the uEXPLORER
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Performance comparison of depth-encoding detectors based on dual-ended readout and different SiPMs for high-resolution PET applications
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Compton PET: a layered structure PET detector with high performance
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Dual-ended readout of bismuth germanate to improve timing resolution in time-of-flight PET
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Discussions with Leaders: A Conversation between Simon Cherry and Johannes Czernin
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2019: an update from the Editor-in-Chief
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First Human Imaging Studies with the EXPLORER Total-Body PET Scanner
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Mini EXPLORER II: a prototype high-sensitivity PET/CT scanner for companion animal whole body and human brain scanning
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