Paul Miller

Recent Publications

2023

Type 2 cytokines sensitize human sensory neurons to itch-associated stimuli
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Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells
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2022

Characterization and Potential Mitigation of Corneal Effects in Nonclinical Toxicology Studies in Animals Administered Depatuxizumab Mafodotin
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Mechanistic insights into the antipruritic effects of lebrikizumab, an anti-IL-13 mAb
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Characterization and Potential Mitigation of Corneal Effects in Nonclinical Toxicology Studies in Animals Administered Depatuxizumab Mafodotin
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2021

Comparison of intraocular pressures estimated by rebound and applanation tonometry in dogs with lens instability: 66 cases (2012-2018)
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Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart
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Evaluation of the effect of disposable tonometer cover brand on performance of Tono-Pen Vet in canine eyes
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Cardiotoxic Potential of Hydroxychloroquine, Chloroquine and Azithromycin in Adult Human Primary Cardiomyocytes
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Determination of a No Observed Effect Level (NOEL) for Beta Glucans following a Single Intravitreal Administration to Female Dutch Belted Rabbits
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Observation of silicone oil within the vitreous and sclera following intravitreal administration of biotherapeutics using insulin syringes in cynomolgus monkeys
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2020

Observation of Silicone Oil Within the Vitreous and Sclera Following Intravitreal Administration of Biotherapeutics Using Insulin Syringes in Cynomolgus Monkeys
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Medical anti-glaucoma therapy: Beyond the drop
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Discovery and characterization of ORM-11372, a novel inhibitor of the sodium-calcium exchanger with positive inotropic activity
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Multiparametric Mechanistic Profiling of Inotropic Drugs in Adult Human Primary Cardiomyocytes
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Functional expression and pharmacological modulation of TRPM3 in human sensory neurons
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Effects of 0.02% netarsudil ophthalmic solution on intraocular pressure of normotensive dogs
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2019

Wound leakage rates of ex vivo uniplanar versus biplanar phacoemulsification clear corneal incisions in dogs
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Human Heart Cardiomyocytes in Drug Discovery and Research: New Opportunities in Translational Sciences
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The West coast regional safety pharmacology society meeting update: Filling translational gaps in safety assessment
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2018

Bimatoprost sustained-release intracameral implant reduces episcleral venous pressure in dogs
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Label-free imaging of atherosclerotic plaques using third-harmonic generation microscopy
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Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular Trabeculae
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Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk
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Ocular Safety of AAV2. 7m8-ChrimsonR-tdTomato (GS030-DP) following intravitreous injection and exposure to 595 nm LED light in blind rd1 mice
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2017

The SPOTS System: An Ocular Scoring System Optimized for Use in Modern Preclinical Drug Development and Toxicology
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Slit Lamp-Based Ocular Scoring Systems in Toxicology and Drug Development: A Literature Survey
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Nonclinical Safety Assessment of Anti-Factor D: Key Strategies and Challenges for the Nonclinical Development of Intravitreal Biologics
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INTRAOCULAR PRESSURE AND EXAMINATION FINDINGS IN THREE SPECIES OF CENTRAL AND SOUTH AMERICAN TREE FROGS (CRUZIOHYLA CRASPEDOPUS, CRUZIOHYLA CALCARIFER, AND ANOTHECA SPINOSA)
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Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human <em>Ex vivo</em> Trabeculae and <em>In silico</em> Ventricular Models Incorporating Inter-Individual Action Potential Variability
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Evaluation of the Toxicity of Intravitreally Injected PLGA Microspheres and Rods in Monkeys and Rabbits: Effects of Depot Size on Inflammatory Response
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MEASURING INTRAOCULAR PRESSURE IN WHITE'S TREE FROGS (LITORIA CAERULEA) BY REBOUND TONOMETRY: COMPARING DEVICE, TIME OF DAY, AND MANUAL VERSUS CHEMICAL RESTRAINT METHODS
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Determination of a No-Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Dutch Belted Rabbits
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The SPOTS system: an ocular scoring system optimized for use in modern preclinical drug development and toxicology
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Calibration of the TonoVet and Tono‐Pen Vet tonometers in the porcine eye
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Preliminary tolerability of iPSC-Derived RPE on PLGA scaffold implantation in RNU Nude Rats
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2016

Evaluation of potential risk factors for development of primary angle-closure glaucoma in Bouviers des Flandres
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Calibration of the TonoVet and Tono-Pen Vet tonometers in the porcine eye
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Bilateral Uveitis and Hyphema in a Catalina Macaw (Ara ararauna × Ara macao ) With Multicentric Lymphoma
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Human ex-vivo action potential model for pro-arrhythmia risk assessment
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α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA<sub>B</sub> receptors
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Species differences in the geometry of the anterior segment differentially affect anterior chamber cell scoring systems in laboratory animals
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2015

Species Differences in the Geometry of the Anterior Segment Differentially Affect Anterior Chamber Cell Scoring Systems in Laboratory Animals
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Clinical Signs and Diagnosis of the Canine Primary Glaucomas
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Functional and Structural Effects of Subretinal Dose Delivery in Mice
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2014

Evaluation of rebound tonometry in red-eared slider turtles (Trachemys scripta elegans)
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Investigation of ocular events associated with taprenepag isopropyl, a topical EP2 agonist in development for treatment of glaucoma
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2013

Iridocorneal angle measurements in mammalian species: normative data by optical coherence tomography
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2012

The effect of topical latanoprost on anterior segment anatomic relationships in normal dogs
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Iridocorneal angle measurements in mammalian species: normative data by optical coherence tomography
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2011

Topical application of 0.005% latanoprost increases episcleral venous pressure in normal dogs
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Subretinal Administration of Fluorescent Microspheres in the Minipig
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Safety And Tolerability Of Retinostat®, A Lentiviral-vector Based Gene Therapy Product For The Treatment Of Wet Age-related Macular Degeneration, In Rabbits And Monkeys
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Commotio retinae and paraocular gland necrosis in rabbits associated with medial ear artery catheters
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2009

Continuous Monitoring of Intraocular Pressure in New Zealand White Rabbits Using Telemetry
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Ocular inflammation in cynomolgus macaques following intravenous administration of a human monoclonal antibody
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Prevention of Laser Photocoagulation Induced Choroidal Neovascularization Lesions by Intravitreal Doses of Ranibizumab in Cynomolgus Monkeys
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2008

Evaluation of EIAV Based Lentiviral Vectors Following Ocular Delivery in the Nonhuman Primate Model: Development of RetinoStat®
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Pachymetry in New Zealand White Rabbits, Beagle Dogs, and Cynomolgus Monkeys.
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Corneal endothelial cell density measurements using noncontact specular microscopy in rabbits, dogs and monkeys
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Standardized Full-Field Electroretinography in Cynomolgus Monkeys
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2006

Safety evaluation of intravitreal administration of VEGF trap in cynomolgus monkeys for 13 weeks.
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2005

Evaluation of intra-and interobserver reliability and image reproducibility to assess usefulness of high-resolution ultrasonography for measurement of anterior segment structures of canine eyes
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2003

26-Week Intravitreal Injection Toxicity Study with rhuFab VEGF in Cynomolgus Monkeys with an 8-Week Recovery
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2001

Safety Evaluation of Differing Schedules of Intravitreal Administration of rhuFab VEGF in Cynomolgus Monkeys for 2 Months
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2000

Safety Evaluation of Intravitreal Administration of rhuFab VEGF in Cynomolgus Monkeys for 3 Months
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