Nader Sheibani

Accreditations

Dr. Sheibani is a Professor in the Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health. He is interested in mechanisms that keep angiogenesis in check and alterations under pathological conditions, such as ischemia or diabetes, that result in ocular neovascularization. He has developed in-vivo mouse models (developing retinal vasculature, oxygen-induced ischemic retinopathy, diabetes, and laser-induced Choroidal neovascularization) and in-vitro cell culture models (retinal endothelial cells, pericytes, astrocytes, choroidal endothelial cells, retinal pigment epithelial cells, corneal endothelial cells, corneal epithelial cells, and trabecular meshwork cells) to study normal and pathological angiogenesis, the molecular and cellular mechanisms that contribute to normal ocular development and function, as well as pathologies associated with eye diseases at the cellular level.

Recent Publications

2024

Fluorimetric detection of DNA methylation by cerium oxide nanoparticles for early cancer diagnosis
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Quantifying nanoscopic alterations associated with mitochondrial dysfunction using three-dimensional single-molecule localization microscopy
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Thrombospondin-1, BIM and CFH polymorphisms and response to anti-VEGF treatment in neovascular age- related macular degeneration patients
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Choroidal Mast Cells and Pathophysiology of Age-Related Macular Degeneration
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2023

AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors
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Construction of an Exudative Age-Related Macular Degeneration Diagnostic and Therapeutic Molecular Network Using Multi-Layer Network Analysis, a Fuzzy Logic Model, and Deep Learning Techniques: Are Retinal and Brain Neurodegenerative…
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Artesunate mitigates choroidal neovascularization and scar formation
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Retinal inflammation in murine models of type 1 and type 2 diabetes with diabetic retinopathy
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Lateralization of the hippocampus: A review of molecular, functional, and physiological properties in health and disease
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THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer
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Thrombospondin-1 in vascular development, vascular function, and vascular disease
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Adenosine Receptors Expression in Human Retina and Choroid with Age-related Macular Degeneration
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Cytochrome P450 1B1 Expression Regulates Intracellular Iron Levels and Oxidative Stress in the Retinal Endothelium
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Vitamin D Receptor Expression Limits the Angiogenic and Inflammatory Properties of Retinal Endothelial Cells
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Connective Tissue Growth Factor: A Key Factor Among Mediators of Tissue Fibrosis
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2022

Assessment of Choroidal Vasculature and Innate Immune Cells in the Eyes of Albino and Pigmented Mice
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Cytochrome P450 1B1: A Key Regulator of Ocular Iron Homeostasis and Oxidative Stress
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Bim Expression Modulates Branching Morphogenesis of the Epithelium and Endothelium
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Smart active-targeting of lipid-polymer hybrid nanoparticles for therapeutic applications: Recent advances and challenges
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Diabetes negatively affects tooth enamel and dentine microhardness: An in-vivo study
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Fingolimod (FTY720), a Sphinogosine-1-Phosphate Receptor Agonist, Mitigates Choroidal Endothelial Proangiogenic Properties and Choroidal Neovascularization
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Bim Expression Promotes the Clearance of Mononuclear Phagocytes during Choroidal Neovascularization, Mitigating Scar Formation in Mice
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Thrombospondin-1 expression and modulation of Wnt and hippo signaling pathways during the early phase of Trypanosoma cruzi infection of heart endothelial cells
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2021

7, 8-Dihydroxyflavone, a TrkB receptor agonist, provides minimal protection against retinal vascular damage during oxygen-induced ischemic retinopathy
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Caffeine Inhibits Choroidal Neovascularization Through Mitigation of Inflammatory and Angiogenesis Activities
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Implication of <em>N</em>-Methyl-d-Aspartate Receptor in Homocysteine-Induced Age-Related Macular Degeneration
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Glimpse into the Cellular Internalization and Intracellular Trafficking of Lipid- Based Nanoparticles in Cancer Cells
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Hypoxic-Ischemic Encephalopathy: Impact on Retinal Neurovascular Integrity and Function
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Silencing of HMGA2 by siRNA Loaded Methotrexate Functionalized Polyamidoamine Dendrimer for Human Breast Cancer Cell Therapy
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Anti-seizure effects of walnut peptides in mouse models of induced seizure: The involvement of GABA and nitric oxide pathways
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Retinopathy of prematurity shows alterations in Vegfa<sub>164</sub> isoform expression
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Hypoxic-ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina
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Targeted Thrombospondin-1 Expression in Ocular Vascular Development and Neovascularization
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Development of an albumin decorated lipid-polymer hybrid nanoparticle for simultaneous delivery of methotrexate and conferone to cancer cells
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2020

A Novel Polyurethane Expandable Root Canal Sealer
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A rapid, simple and ultrasensitive spectrofluorimetric method for the direct detection of metformin in real samples based on a nanoquenching approach
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Noninvasive temporal detection of early retinal vascular changes during diabetes
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Myeloid-Derived TSP1 (Thrombospondin-1) Contributes to Abdominal Aortic Aneurysm Through Suppressing Tissue Inhibitor of Metalloproteinases-1
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Thrombospondin-1 Plays an Essential Role in Yes-Associated Protein Nuclear Translocation during the Early Phase of <em>Trypanosoma cruzi</em> Infection in Heart Endothelial Cells
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Moderately Acidic pH Promotes Angiogenesis: An In Vitro and In Vivo Study
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Deletion of Thioredoxin-Interacting Protein (TXNIP) Abrogates High Fat Diet-induced Retinal Leukostasis, Barrier Dysfunction and Microvascular Degeneration in a Mouse Obesity Model
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Bim expression modulates the pro-inflammatory phenotype of retinal astroglial cells
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Retinal astrocytes transcriptome reveals Cyp1b1 regulates the expression of genes involved in cell adhesion and migration
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Neurovascular Organotypic Culture Models Using Induced Pluripotent Stem Cells to Assess Adverse Chemical Exposure Outcomes
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Long-term evaluation of retinal morphology and function in a mouse model of oxygen-induced retinopathy
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In Vivo Imaging of Schlemm's Canal and Limbal Vascular Network in Mouse Using Visible-Light OCT
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Surface plasmon resonance, fluorescence, and molecular docking studies of bovine serum albumin interactions with natural coumarin diversin
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2019

Synthesis, characterization, anti-proliferative properties and DNA binding of benzochromene derivatives: Increased Bax/Bcl-2 ratio and caspase-dependent apoptosis in colorectal cancer cell line
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Tunicamycin-induced photoreceptor atrophy precedes degeneration of retinal capillaries with minimal effects on retinal ganglion and pigment epithelium cells
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1,25(OH)<sub>2</sub>D<sub>3</sub> regulates the proangiogenic activity of pericyte through VDR-mediated modulation of VEGF production and signaling of VEGF and PDGF receptors
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Multispectral and computational probing of the interactions between sitagliptin and serum albumin
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Synergistic inhibition of catalase activity by food colorants sunset yellow and curcumin: An experimental and MLSD simulation approach
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Bcl-2 Expression in Pericytes and Astrocytes Impacts Vascular Development and Homeostasis
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Quantitative proteomic study of arsenic treated mouse liver sinusoidal endothelial cells using a reverse super-SILAC method
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Cyp1b1-deficient retinal astrocytes are more proliferative and migratory and are protected from oxidative stress and inflammation
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Steered molecular dynamic simulations of conformational lock of Cu, Zn-superoxide dismutase
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Novel Paracrine Functions of Smooth Muscle Cells in Supporting Endothelial Regeneration Following Arterial Injury
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The impact of water molecules on binding affinity of the anti-diabetic thiazolidinediones for catalase: Kinetic and mechanistic approaches
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