Leonard Levin

Accreditations
Disciplines

Dr. Levin is a visual scientist and neuro-ophthalmologist at the University of Wisconsin School of Medicine and Public Health and the University of Montreal. He specializes in diseases of the optic nerve, and studies optic neuropathies and retinal ganglion cell death at the molecular, biochemical, and cellular level. He serves as a consultant to pharmaceutical companies in the areas of neuroprotection and its application to human disease, including glaucoma.

Recent Publications

2024

In Vivo Imaging of Secondary Neurodegeneration Associated With Phosphatidylserine Externalization Along Axotomized Axons
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2023

Translational roadmap for regenerative therapies of eye disease
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2022

Modeling Reactive Oxygen Species-Induced Axonal Loss in Leber Hereditary Optic Neuropathy
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Equity, diversity, and inclusion landscape in Canadian postgraduate medical education for ophthalmology
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Increasing equity, diversity, and inclusion in the ophthalmology CaRMS selection process: ACUPO recommendations
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Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future
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Author Correction: Regenerative and restorative medicine for eye disease
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Pivotal roles for membrane phospholipids in axonal degeneration
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Regenerative and restorative medicine for eye disease
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A quantitative approach to the spread of variance in translational research using Monte Carlo simulation
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2021

Report From the National Eye Institute Workshop on Neuro-Ophthalmic Disease Clinical Trial Endpoints: Optic Neuropathies
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Exploring Ophthalmologists' Adoption of Telemedicine during the COVID-19 Pandemic: A Mixed Methods Study
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Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma
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Axonal degeneration induces distinct patterns of phosphatidylserine and phosphatidylethanolamine externalization
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Predicting Absorption-Distribution Properties of Neuroprotective Phosphine-Borane Compounds Using In Silico Modeling and Machine Learning
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2020

Crohn-related Chronic Relapsing Inflammatory Optic Neuropathy
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Author Correction: Propagation and Selectivity of Axonal Loss in Leber Hereditary Optic Neuropathy
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2019

Randomized Controlled Phase 2a Study of RPh201 in Previous Nonarteritic Anterior Ischemic Optic Neuropathy
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A First-in-Human Phase 1 Randomized Single and Multiple Ascending Dose Study of RPh201 in Healthy Volunteers
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Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration
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Propagation and Selectivity of Axonal Loss in Leber Hereditary Optic Neuropathy
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2018

Neuroprotection in Optic Neuropathy
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2017

The Academic-Industrial Complexity: Failure to Launch
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Cobalamin-Associated Superoxide Scavenging in Neuronal Cells Is a Potential Mechanism for Vitamin B<sub>12</sub>-Deprivation Optic Neuropathy
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Glaucoma and the brain: Trans-synaptic degeneration, structural change, and implications for neuroprotection
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Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy: Response
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Neuroprotection in Glaucoma: Animal Models and Clinical Trials
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Polyester-based microdisc systems for sustained release of neuroprotective phosphine-borane complexes
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Special Commentary: Early Clinical Development of Cell Replacement Therapy: Considerations for the National Eye Institute Audacious Goals Initiative
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Axonal Degeneration in Retinal Ganglion Cells Is Associated with a Membrane Polarity-Sensitive Redox Process
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New Treatments in Neuro-Ophthalmology: The Role for Evidence
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2016

Neuroprotection for glaucoma: Requirements for clinical translation
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Detection and measurement of clinically meaningful visual field progression in clinical trials for glaucoma
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Translational Pharmacology in Glaucoma Neuroprotection
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Intracellular disulfide reduction by phosphine-borane complexes: Mechanism of action for neuroprotection
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2015

Induction of Neuronal Morphology in the 661W Cone Photoreceptor Cell Line with Staurosporine
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Reactive Oxygen Species in Mitochondrial Optic Neuropathies: Response
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Glaucoma as a neurodegenerative disease
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Borane-protected phosphines are redox-active radioprotective agents for endothelial cells
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Superoxide generation explains common features of optic neuropathies associated with cecocentral scotomas
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2012

Optic nerve disease and axon pathophysiology
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Solving the lost in translation problem: improving the effectiveness of translational research
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Retrograde and Wallerian axonal degeneration occur synchronously after retinal ganglion cell axotomy
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Redox proteomic identification of visual arrestin dimerization in photoreceptor degeneration after photic injury
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High-content neurite development study using optically patterned substrates
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Ordering of neuronal apoptosis signaling: a superoxide burst precedes mitochondrial cytochrome c release in a growth factor deprivation model
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Superoxide signaling and cell death in retinal ganglion cell axotomy: effects of metallocorroles
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Author response: Bayesian estimation of sensitivity of temporal artery biopsies
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2011

Laser-based single-axon transection for high-content axon injury and regeneration studies
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Clinical evidence for neuroprotection in glaucoma
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A cell-permeable phosphine-borane complex delays retinal ganglion cell death after axonal injury through activation of the pro-survival extracellular signal-regulated kinases 1/2 pathway
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How should patients with indirect traumatic optic neuropathy be treated?
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