Lauren Trepanier

Accreditations

Dr. Trepanier is a Professor of Medicine at the University of Wisconsin School of Veterinary Medicine. She is Board Certified by the American College of Veterinary Internal Medicine and the American College of Veterinary Clinical Pharmacology. Her research interests include idiosyncratic drug toxicity, pharmacogenetics, and comparative drug biotransformation among species.

Recent Publications

2024

Oral cinacalcet administration decreases serum ionized calcium and parathyroid hormone concentrations in healthy dogs
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Environmental radon, fracking wells, and lymphoma in dogs
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Urinary and household chemical exposures in pet dogs with urothelial cell carcinoma
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2023

Potential mechanism for hyperhomocysteinemia in Greyhound dogs
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2022

Genotoxicity from metronidazole detected in vitro, but not in vivo, in healthy dogs in a randomized clinical trial
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Environmental exposures and lymphoma risk: a nested case-control study using the Golden Retriever Lifetime Study cohort
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Incidence of hepatopathies in dogs administered zonisamide orally: A retrospective study of 384 cases
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2021

Risk of bladder cancer and lymphoma in dogs is associated with pollution indices by county of residence
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Environmental chemical exposures in the urine of dogs and people sharing the same households
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2020

Plasma and urinary F<sub>2</sub>-isoprostane markers of oxidative stress are increased in cats with early (stage 1) chronic kidney disease
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Biochemical, functional, and histopathologic characterization of lomustine-induced liver injury in dogs
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Genetic and environmental risk for lymphoma in boxer dogs
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2019

Glutathione S-transferase theta genotypes and environmental exposures in the risk of canine transitional cell carcinoma
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Prospective crossover clinical trial comparing transdermal with oral phenobarbital administration in epileptic cats
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2018

RNA expression profiling in sulfamethoxazole-treated patients with a range of in vitro lymphocyte cytotoxicity phenotypes
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Evaluation of potential serum biomarkers of hepatic fibrosis and necroinflammatory activity in dogs with liver disease
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2017

Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis
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Hepatic expression profiles in retroviral infection: relevance to drug hypersensitivity risk
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2016

Immunogenicity of trimethoprim/sulfamethoxazole in a macaque model of HIV infection
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Genome-Wide Association Study in Immunocompetent Patients with Delayed Hypersensitivity to Sulfonamide Antimicrobials
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2015

Transient cold agglutinins associated with Mycoplasma cynos pneumonia in a dog
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Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy
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2014

Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women
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Therapeutic serum phenobarbital concentrations obtained using chronic transdermal administration of phenobarbital in healthy cats
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2013

Cutaneous pythiosis in two dogs from Wisconsin, USA
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Use of linezolid to treat MRSP bacteremia and discospondylitis in a dog
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Idiosyncratic drug toxicity affecting the liver, skin, and bone marrow in dogs and cats
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Applying pharmacokinetics to veterinary clinical practice
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Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics
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2012

Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity
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Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis
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2011

Individual variability in the detoxification of carcinogenic arylhydroxylamines in human breast
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Dapsone-associated methemoglobinemia in a patient with slow NAT2*5B haplotype and impaired cytochrome b5 reductase activity
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Evaluation of sulfonamide detoxification pathways in haematologic malignancy patients prior to intermittent trimethoprim-sulfamethoxazole prophylaxis
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2010

Clinical presentation of 26 anaplasma phagocytophilum-seropositive dogs residing in an endemic area
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Antifungal treatment of small animal veterinary patients
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Combined ascorbate and glutathione deficiency leads to decreased cytochrome b5 expression and impaired reduction of sulfamethoxazole hydroxylamine
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Acute vomiting in cats: rational treatment selection
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2009

Cytochrome b5 and NADH cytochrome b5 reductase: genotype-phenotype correlations for hydroxylamine reduction
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