Dennis Hartigan-O'Connor

Accreditations
Disciplines

Dr. Hartigan-O'Connor is an Assistant Professor of Medicine at the University of California, Davis. His research is focused on mechanisms of tolerance and immune privilege, both in the adult eye and in the developing fetus. His most recent work focuses on resilience of retinal immune privilege to inflammatory insults and neovascularization, as well as the potential of immunosuppressive drugs to maintain privilege despite these challenges. His work has been published in leading journals including Science Translational Medicine and the Journal of Experimental Medicine.

Recent Publications

2023

Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo
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Dynamics of temporal immune responses in nonhuman primates and humans immunized with COVID-19 vaccines
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First Dark Matter Search Results from the LUX-ZEPLIN (LZ) Experiment
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FcRγ- NK Cell Induction by Specific Cytomegalovirus and Expansion by Subclinical Viral Infections in Rhesus Macaques
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Encapsulated Allografts Preclude Host Sensitization and Promote Ovarian Endocrine Function in Ovariectomized Young Rhesus Monkeys and Sensitized Mice
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SIV clearance from neonatal macaques following transient CCR5 depletion
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Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction
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2022

Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections
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Cytomegalovirus infection disrupts the influence of short-chain fatty acid producers on Treg/Th17 balance
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HIV T-cell immunogen design and delivery
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T-Follicular-Like CD8<sup>+</sup> T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG
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Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung inflammation
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Human Immunodeficiency Virus-1 Latency Reversal <em>via</em> the Induction of Early Growth Response Protein 1 to Bypass Protein Kinase C Agonist-Associated Immune Activation
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Enteric Viruses Nucleic Acids Distribution along the Digestive Tract of Rhesus Macaques with Idiopathic Chronic Diarrhea
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Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome
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Translational Utility of the Nonhuman Primate Model
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Nonhuman Primates in Translational Research
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Randomized controlled trial of early, small-volume formula supplementation among newborns: A study protocol
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2021

Idiopathic Chronic Diarrhea in Rhesus Macaques Is Not Associated with Enteric Viral Infections
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SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma
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Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation
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Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity reduces lung inflammation
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Immune response dynamics in COVID-19 patients to SARS-CoV-2 and other human coronaviruses
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Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques
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Cytomegalovirus mediates expansion of IL-15-responsive innate-memory cells with SIV killing function
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Transient Effect of Infant Formula Supplementation on the Intestinal Microbiota
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SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
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2020

Fetal Rhesus Monkey First Trimester Zika Virus Infection Impacts Cortical Development in the Second and Third Trimesters
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TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses
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RhCMV serostatus and vaccine adjuvant impact immunogenicity of RhCMV/SIV vaccines
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SARS-CoV-2 infection induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
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SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques
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SARS-CoV-2 surveillance for a non-human primate breeding research facility
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2019

Cytomegalovirus-vectored vaccines for HIV and other pathogens
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Neutralization of rhesus cytomegalovirus IL-10 reduces horizontal transmission and alters long-term immunity
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Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate
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2018

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade
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Idiopathic Colitis in Rhesus Macaques Is Associated With Dysbiosis, Abundant Enterochromaffin Cells and Altered T-Cell Cytokine Expression
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Subclinical Cytomegalovirus Infection Is Associated with Altered Host Immunity, Gut Microbiota, and Vaccine Responses
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The Effect of Early Limited Formula on Breastfeeding, Readmission, and Intestinal Microbiota: A Randomized Clinical Trial
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HIV latency is reversed by ACSS2-driven histone crotonylation
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2017

Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success
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IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8<sup>+</sup> T Cell Responses in Acute Simian Immunodeficiency Virus Infection
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Depletion of Gut-Resident CCR5<sup>+</sup> Cells for HIV Cure Strategies
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2015

Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge
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Persistent effects of early infant diet and associated microbiota on the juvenile immune system
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2014

Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems
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2013

Monocyte activation by interferon α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection
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IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia
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2012

SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment
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2011

Th17 cells and regulatory T cells in elite control over HIV and SIV
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The human fetal immune response to hepatitis C virus exposure in utero
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2010

Development of cytomegalovirus (CMV) immune recovery uveitis is associated with Th17 cell depletion and poor systemic CMV-specific T cell responses
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