Dr. Murphy is a founder, serves as CEO, and provides consulting in veterinary ophthalmology.
Dr. Murphy is a Board Certified Veterinary Ophthalmologist, and Professor of Comparative Ophthalmology in the Schools of Veterinary Medicine & Medicine, University of California-Davis. Dr. Murphy has advanced training and expertise in corneal diseases and surgery, comparative physiological optics, comparative ocular anatomy, as well as ocular diseases of laboratory and exotic animal species.
His laboratory has several active areas of research:
- Modulation of cell behaviors by biophysical attributes of the extracellular matrix: With many collaborators, Dr. Murphy is determining how biophysical attributes (nanoscale topography and compliance) of the extracellular matrix modulate fundamental cell behaviors such as orientation, adhesion, migration differentiation and proliferation. These studies have relevance to improved design of biomaterials as well as increasing our understanding of the microenvironment of cells in health and disease.
- Modulation of wound healing using engineering principals: A large interdisciplinary team is engaged in developing novel approaches to accelerate wound healing of the cornea and skin through funtionalzing wound beds rather than treating with standard soluble factors. The central concept is that improved wound healing outcomes can be achieved through "changing the wound" surface chemistry and biophysical attributes rather than treating the wound with soluble factors.
- Comparative ocular functional morphology: Dr. Murphy studies how various animals have evolved unique optical adaptations for optimizing their visual performance under challenging environmental conditions.
- Development of improved solutions for organ storage prior to transplantation: In collaboration with Professor Jon McAnulty, transplant surgeon at the School of Veterinary Medicine, Dr. Murphy has found that the addition of a unique combination of trophic factors can markedly extend the time that an organ can be stored and improve its performance once it is transplanted.
Standard services to industry provided by Dr. Murphy's laboratories include performance of in-vitro cytotoxicity assays using primary cultures from human ocular cell lines (cornea and trabecular meshwork) and conducting proof of principal studies using animal models.