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Brian Christian

Vision Scientist
Accreditations
PhD
DABT
Disciplines
Regulatory Affairs
Ocular Toxicology

Dr. Christian is a regulatory toxicologist with over 30 years of experience in the contract pharmaceutical research industry.  Prior to joining OSOD he served as the scientific lead for the ocular toxicology services offered at Covance/Labcorp Laboratories which included planning and directing nonclinical toxicology and pharmacology studies as senior study director.  Brian is a diplomate of the American Board of Toxicology and has served on the Executive Committee of the Ocular Toxicology Specialty Section of the Society of Toxicology.    

Recent Publications

2021

Semiquantitative Methods for GFP Immunohistochemistry and In Situ Hybridization to Evaluate AAV Transduction of Mouse Retinal Cells Following Subretinal Injection

Toxicologic Pathology, 49(3), pp.537-543

Huet, F., Miller, J., Miller, P.E., Hayden, C., Glick, J.J., Bentley, A., De Benedetto, C., McPherson, L.E. and Turner, O.C., 2021
Semiquantitative Methods for GFP Immunohistochemistry and In Situ Hybridization to Evaluate AAV Transduction of Mouse Retinal Cells Following Subretinal Injection
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2019

Normative Values for Multifocal ERGs Recorded from Cynomolgus Macaques in a Non-clinical Setting

In Investigative Ophthalmology & Visual Science (Vol. 60, No. 9)

Krakova, Y., Kim, C.B., Eaton, S., Christian, B.J., Budzynski, E., Miller, J., Nork, T.M., Murphy, C.J. and Ver Hoeve, J.N., 2019, July
Normative Values for Multifocal ERGs Recorded from Cynomolgus Macaques in a Non-clinical Setting
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2018

Ocular Safety of AAV2. 7m8-ChrimsonR-tdTomato (GS030-DP) following intravitreous injection and exposure to 595 nm LED light in blind rd1 mice

Investigative Ophthalmology & Visual Science, 59(9), pp.5658-5658

Christian, B.J., Sorden, S.D., Ward, M., Nork, T.M., Miller, P.E., Douar, A., Thomasson, N. and Bouquet, C., 2018
Ocular Safety of AAV2. 7m8-ChrimsonR-tdTomato (GS030-DP) following intravitreous injection and exposure to 595 nm LED light in blind rd1 mice
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2017

Preliminary tolerability of iPSC-Derived RPE on PLGA scaffold implantation in RNU Nude Rats

American Society of Gene & Cell Therapy Annual Meeting. Mol Ther; 25(5S1)

Mancl B., Christian B.J., Nork, T.M., Miller P.E., Sorden S., Maminishkis A., Khristov V., Jha B., Bharti K. 2017
Preliminary tolerability of iPSC-Derived RPE on PLGA scaffold implantation in RNU Nude Rats
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2016

Variability in the Electroretinographic Response of Laboratory Animals

 Investigative Ophthalmology & Visual Science, 57(12), pp.5766-5766

Ver Hoeve, J.N., Kim, C.B., Nork, T.M., Eaton, S., Christian, B.J. and Murphy, C.J., 2016
Variability in the Electroretinographic Response of Laboratory Animals
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2015

Functional and Structural Effects of Subretinal Dose Delivery in Mice

Investigative Ophthalmology & Visual Science, 56(7), pp.245-245

Christian, B.J., Budzynski, E., Sonnentag, P., Miller, P.E., Ver Hoeve, J.N., Kim, C.B., Rasmussen, C.A., Fass, N., Bentley, E. and Nork, T.M., 2015
Functional and Structural Effects of Subretinal Dose Delivery in Mice
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2014

Gender Differences in Anesthetized Primate ERG and Full-field Flash VEP

Investigative Ophthalmology & Visual Science, 55(13), pp.5130-5130

Ver Hoeve, J.N., Glatting, B., McIntyre, K.B., Christian, B.J., Nork, T.M. and Kim, C.B., 2014
Gender Differences in Anesthetized Primate ERG and Full-field Flash VEP
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2013

Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals

Molecular and Integrative Toxicology, Springer, New York, pp 53-121 (2013)

Nork, T. M., Rassmussen, C. A., Christian, B. J., Croft, M. A, and Murphy, C. J
Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals
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Inner Nuclear Layer (INL) Cystoid Spaces (Lacunae) Observed in Experimental Glaucoma and Axotomy in Non-Human Primates (NHPs)

 Investigative Ophthalmology & Visual Science, 54(15), pp.4818-4818

Nork, T.M., Rasmussen, C., Ver Hoeve, J., Murphy, C., Neider, M., Kim, C. and Christian, B., 2013
Inner Nuclear Layer (INL) Cystoid Spaces (Lacunae) Observed in Experimental Glaucoma and Axotomy in Non-Human Primates (NHPs)
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Electrophysiologic Correlates of RNFL Thickness in Experimental Glaucoma

Investigative Ophthalmology & Visual Science, 54(15), pp.794-794

Ver Hoeve, J., Kim, C., Rasmussen, C., Murphy, C., Christian, B. and Nork, T.M., 2013
Electrophysiologic Correlates of RNFL Thickness in Experimental Glaucoma
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2011

Subretinal Administration of Fluorescent Microspheres in the Minipig

Investigative Ophthalmology & Visual Science, 52(14), pp.1358-1358.

Christian, B.J., Rauschenberger, M., Bentley, E., Rasmussen, C.A., Wabers, H.D., Miller, P.E., Murphy, C.J. and Nork, T.M., 2011
Subretinal Administration of Fluorescent Microspheres in the Minipig
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Safety And Tolerability Of Retinostat®, A Lentiviral-vector Based Gene Therapy Product For The Treatment Of Wet Age-related Macular Degeneration, In Rabbits And Monkeys

 Investigative Ophthalmology & Visual Science, 52(14), pp.488-488

Ellis, S., Widdowson, P., Binley, K., Nork, T.M., Miller, P., Bantseev, V., Christian, B., Mitrophanous, K. and Naylor, S., 2011
Safety And Tolerability Of Retinostat®, A Lentiviral-vector Based Gene Therapy Product For The Treatment Of Wet Age-related Macular Degeneration, In Rabbits And Monkeys
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Inter-ocular And Inter-subject Variability In The Full-field Electroretinograms Of Rabbits And Monkeys

 Investigative Ophthalmology & Visual Science, 52(14), pp.703-703

Ver Hoeve, J.N., Kim, C.B., Nork, T.M., Christian, B.J. and Murphy, C.J., 2011
Inter-ocular And Inter-subject Variability In The Full-field Electroretinograms Of Rabbits And Monkeys
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2010

Supplemental Clock-Hour Fluorescein Angiography (FA) Scoring and Image Analysis of Laser-Induced Choroidal Neovascularization (CNV) Lesions in Cynomolgus Monkeys

 Investigative Ophthalmology & Visual Science, 51(13), pp.6155-6155

Bantseev, V., Streit, T.M., Urech, D.M., Nork, T.M., Christian, B.J. and Lam, T.T., 2010.
Supplemental Clock-Hour Fluorescein Angiography (FA) Scoring and Image Analysis of Laser-Induced Choroidal Neovascularization (CNV) Lesions in Cynomolgus Monkeys
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INO-8875, an adenosine A1 agonist, lowers intraocular pressure through the conventional outflow pathway

 Investigative Ophthalmology & Visual Science, 51(13), pp.3238-3238

Kim, N., Crosson, C., Lam, T., Christian, B., Busse, C., Cantone, G., Baumgartner, R., McCauley, T. and McVicar, W., 2010.
INO-8875, an adenosine A1 agonist, lowers intraocular pressure through the conventional outflow pathway
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Spectral domain OCT segmentation accuracy in monkeys

 Investigative Ophthalmology & Visual Science, 51(13), pp.4401-4401

McIntyre, K.B., Rasmussen, C.A., Goulding, A.K., Bantseev, V., Ver Hoeve, J.N., Kaufman, P.L., Christian, B.J. and Nork, T.M., 2010.
Spectral domain OCT segmentation accuracy in monkeys
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2009

Bilateral optic atrophy: a background finding in cynomolgus macaques used in toxicologic research

Investigative Ophthalmology & Visual Science, 50(13), pp.5344-5344

Dubielzig, R.R., Leedle, R., Nork, T.M., VerHoeve, J.A. and Christian, B.J., 2009.
Bilateral optic atrophy: a background finding in cynomolgus macaques used in toxicologic research
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Continuous Monitoring of Intraocular Pressure in New Zealand White Rabbits Using Telemetry

Toxicologist Supplement (2009)

Lam, T. T., Miller, P. E., Antonio, Z., Taschwer, M., Banstseev, V., and Christian, B. J.
Continuous Monitoring of Intraocular Pressure in New Zealand White Rabbits Using Telemetry
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Ocular inflammation in cynomolgus macaques following intravenous administration of a human monoclonal antibody

 International journal of toxicology, 28(1), pp.5-16

Martin, P.L., Miller, P.E., Mata, M. and Christian, B.J., 2009.
Ocular inflammation in cynomolgus macaques following intravenous administration of a human monoclonal antibody
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2008

Evaluation of EIAV Based Lentiviral Vectors Following Ocular Delivery in the Nonhuman Primate Model: Development of RetinoStat®

Investigative Ophthalmology & Visual Science, 49(13), pp.5340-5340

Binley, K.M., Iqball, S., Nork, T.M., Miller, P.E., Christian, B.J., Kan, O., Rasmussen, C., Kim, C.B.Y., Ver Hoeve, J.N. and Naylor, S., 2008.
Evaluation of EIAV Based Lentiviral Vectors Following Ocular Delivery in the Nonhuman Primate Model: Development of RetinoStat®
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Pachymetry in New Zealand White Rabbits, Beagle Dogs, and Cynomolgus Monkeys.

Investigative Ophthalmology & Visual Science, 49(13), pp.645-645

McCulloh, R.J., Holley, G.P., Miller, P.E., Miller, J.M., Edelhauser, H.F., Leatherberry, G., Luetkehoelter, K.B., Christian, B.J., Murphy, C.J. and Lam, T.T., 2008
Pachymetry in New Zealand White Rabbits, Beagle Dogs, and Cynomolgus Monkeys.
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Corneal endothelial cell density measurements using noncontact specular microscopy in rabbits, dogs and monkeys

Investigative Ophthalmology & Visual Science, 49(13), pp.2819-2819

Miller, J.M., Holley, G.P., Miller, P.E., Edelhauser, H.F., Murphy, C.J., McCulloh, R.J., Christian, B.J., Smith, P.B. and Lam, T.T., 2008.
Corneal endothelial cell density measurements using noncontact specular microscopy in rabbits, dogs and monkeys
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Standardized Full-Field Electroretinography in Cynomolgus Monkeys

 Investigative Ophthalmology & Visual Science, 49(13), pp.5816-5816

Ver Hoeve, J.N., Kim, C.B.Y., Nork, T.M., Christian, B.J. and Miller, P.E., 2008.
Standardized Full-Field Electroretinography in Cynomolgus Monkeys
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2006

Safety evaluation of intravitreal administration of VEGF trap in cynomolgus monkeys for 13 weeks.

Investigative Ophthalmology & Visual Science, 47(13), pp.1751-1751.

Zimmer, E., Christian, B.J., Miller, P.E., Nork, M.T., VerHoeve, J.N., Murphy, C.J., Miller, J.M., Leedle, R.A., Lesniak, J. and Bentley, E
Safety evaluation of intravitreal administration of VEGF trap in cynomolgus monkeys for 13 weeks.
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2003

Characterization of a Monkey Model of Laser-Induced Choroidal Neovascularization (CNV)

The Toxicologist, 72 (S-1): 311, (2003)

Christian, B. J., Nork, T. M, Leedle, R. A., Miller, J. M., and O'Neill, C. A.
Characterization of a Monkey Model of Laser-Induced Choroidal Neovascularization (CNV)
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26-Week Intravitreal Injection Toxicity Study with rhuFab VEGF in Cynomolgus Monkeys with an 8-Week Recovery

 Association for Research in Vision and Ophthalmology Annual Meeting. Invest Ophthalmol Vis Sci., 44 – electronic abstract (2003).

O'Neill, C. A., Miller, P. E., Christian, B. J., Beyer, J. C., Bentley, E., Abrams, G. A., Verhoeve, J. N., Nork, T. M., Leedle, R. A., Dubielzig, R. R., Albert, D. M., and Murphy, C. J.
26-Week Intravitreal Injection Toxicity Study with rhuFab VEGF in Cynomolgus Monkeys with an 8-Week Recovery
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2001

Safety Evaluation of Differing Schedules of Intravitreal Administration of rhuFab VEGF in Cynomolgus Monkeys for 2 Months

Toxicologist, 60 (1):97 (2001).

O’Neill, C. A, Miller, P., Christian B. J., Leatherberry, G., Miller, J., Leedle, R., Dubeilzig, R. R., Albert, D. M., Beyer, J. C., Nork, T. M., Wabers, H., Neider, M., and Murphy, C. J.
Safety Evaluation of Differing Schedules of Intravitreal Administration of rhuFab VEGF in Cynomolgus Monkeys for 2 Months
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2000

Safety Evaluation of Intravitreal Administration of rhuFab VEGF in Cynomolgus Monkeys for 3 Months

Invest Ophthalmol Vis Sci, 41 (4):S142 (2000).

O’Neill, C. A, Christian B. J., Murphy, C. J., Miller, P., Verhoeve, J., Leedle, R., Dubeilzig, R. R., Beyer, J. C., Albert, D. M., and Davis, M
Safety Evaluation of Intravitreal Administration of rhuFab VEGF in Cynomolgus Monkeys for 3 Months
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