Ala Moshiri

Accreditations

Dr. Moshiri’s commitment to academic medicine is founded on his scientific interest in retinal genetics and retinal stem cell biology, and he pursues an active laboratory research program. His research background is in the embryonic development of the retina. Under the supervision of Professor Thomas A. Reh at the University of Washington in Seattle, Dr. Moshiri earned a Ph.D. in Neurobiology studying the genetic control of retinal stem cells during eye development. He applied these studies from the embryonic retina to replace retinal cells after injury in adult animals.

His current research in the laboratory is an extension of the earlier experiments during his Ph.D. studies. Dr. Moshiri is actively involved in the study of how retinal photoreceptors, called rods and cones, function. He also focuses on how to promote the survival of these photoreceptor cells, and how to replace them using stem cells and gene therapy. Dr. Moshiri has a special interest in genetic eye diseases like Retinitis Pigmentosa, Stargardt disease, Albinism, and other related conditions where rods and cones do not function properly. He hopes his research will contribute to novel therapies for these hereditary retinal diseases.

His clinical expertise includes all diseases of the retina, including all forms of Macular Degeneration, Retinal Vascular and Inflammatory diseases, medical and surgical management of Diabetic Retinopathy, and all surgical diseases of the retina, including Macular Hole, Macular Pucker, and Retinal Detachment. Dr. Moshiri particularly enjoys seeing patients with difficult-to-diagnose or rare conditions that have eluded other specialists.

Recent Publications

2023

Cost-Utility Comparison of Bevacizumab and Aflibercept in the Treatment of Central or Hemiretinal Vein Occlusion in the SCORE2 Trial
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Real-World Experience Using Intravitreal Brolucizumab Alone or in Combination with Aflibercept in the Management of Neovascular Age-Related Macular Degeneration
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Four-Year Visual Outcomes in the Protocol W Randomized Trial of Intravitreous Aflibercept for Prevention of Vision-Threatening Complications of Diabetic Retinopathy
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Genome-wide screening reveals the genetic basis of mammalian embryonic eye development
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A Spontaneous Nonhuman Primate Model of Myopic Foveoschisis
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2022

OCT Predictors of Treatment Discontinuation in Eyes with Retinal Vein Occlusion and Macular Edema
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Silicone Oil-Induced Glaucomatous Neurodegeneration in Rhesus Macaques
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Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes
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Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure
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Long-Term Retinal Vascular Changes in Age-Related Macular Degeneration Measured Using Optical Coherence Tomography Angiography
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Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death
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Retinal dystrophies: A look beyond the eyes
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Baseline Characteristics and Outcomes After Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema in Participants With Hemiretinal Vein Occlusion Compared With Participants With Central Retinal Vein Occlusion: Study of…
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Retinal organoids derived from rhesus macaque iPSCs undergo accelerated differentiation compared to human stem cells
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2021

Clinical presentation, treatment, and genetic and histopathological analysis of juvenile cataracts and secondary glaucoma in a rhesus macaque (Macaca mulatta)
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Intraocular Pressure-Related Events After Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema Due to Central Retinal Vein Occlusion or Hemiretinal Vein Occlusion: SCORE2 Report 16 on a Secondary Analysis of a Randomized…
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Age-related changes in the rhesus macaque eye
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Expanded Clinical Spectrum of Pentosan Polysulfate Maculopathy: A Macula Society Collaborative Study
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Animals Models of Inherited Retinal Disease
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Advanced Retinal Imaging and Ocular Parameters of the Rhesus Macaque Eye
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Intraoperative Retinal Changes May Predict Surgical Outcomes After Epiretinal Membrane Peeling
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MicroRNA Signatures of the Developing Primate Fovea
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NATURAL HISTORY AND PREDICTORS OF VISION LOSS IN EYES WITH DIABETIC MACULAR EDEMA AND GOOD INITIAL VISUAL ACUITY
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Involving Patients in Their Own Health Care Choices-Altruism Begets Altruism
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Identification of Patients with Pentosan Polysulfate Sodium-Associated Maculopathy through Screening of the Electronic Medical Record at an Academic Center
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Biallelic UBE4A loss-of-function variants cause intellectual disability and global developmental delay
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2020

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density
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Off-Label Use as a Standard of Care
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Quantitative Fundus Autofluorescence in Rhesus Macaques in Aging and Age-Related Drusen
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Imaging oxygenation of retinal capillaries with depth resolution
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Phase I/II randomized study of proton beam with anti-VEGF for exudative age-related macular degeneration: long-term results
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2019

Retinal Vessel Density in Exudative and Nonexudative Age-Related Macular Degeneration on Optical Coherence Tomography Angiography
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Real-world management and long-term outcomes of diabetic macular oedema with good visual acuity
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Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice
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Long-term natural history of idiopathic epiretinal membranes with good visual acuity
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The Management of Retinal Detachment: Techniques and Perspectives 2018
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2018

Chronic lymphocytic leukaemia presenting as branch retinal artery occlusion and optic disc infiltration
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Identification of genetic elements in metabolism by high-throughput mouse phenotyping
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2017

The Management of Retinal Detachment: Techniques and Perspectives
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OUTCOMES OF PNEUMATIC RETINOPEXY PERFORMED BY VITREORETINAL FELLOWS
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Macular Fluid Reduces Reproducibility of Choroidal Thickness Measurements on Enhanced Depth Optical Coherence Tomography
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